Comparison of cytogenetics with FISH in 40 myelodysplastic syndrome patients
Chauffaille, M. D.
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Karyotyping is important for diagnosis and prognosis of myelodysplastic syndrome (MDS). Using fluorescence in situ hybridization (FISH) either mitotic or interphase cells can be analyzed and a higher number of cells can be screened. This study evaluated the effectiveness of FISH in detecting the most common chromosomal abnormalities [-5/del 5q/-7/+8/del 11q23 and -Y] in 40 patients with MDS. Karyotype detected abnormalities in 35.2% of the patients and FISH in 35%, while some abnormalities remained undetected by each approach but the association of both methods increased the detection rate up to 40%. (C) 2002 Elsevier B.V. All rights reserved.
CitationLeukemia Research. Oxford: Pergamon-Elsevier B.V., v. 26, n. 11, p. 993-996, 2002.
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