Rheumatic fever and post-streptococcal arthritis

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Data
2002-07-01
Autores
Hilario, MOE
Terreri, MTSLRA
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Rheumatic fever resulting from group A beta-haemolytic Streptococcus infection continues to be a prevalent disease and an important cause of morbidity and mortality in developing countries. Molecular mimicry and CD4 T lymphocytes, interleukins and adhesion molecules play a crucial role in the pathogenesis of this disease. Arthritis, followed by carditis and chorea, are the main manifestations of the disease. Evidence of asymptomatic carditis has been increasing; however, abnormality identified by echo-Doppler evaluation is not considered as a criterion for diagnosis of rheumatic carditis. Benzathine penicillin is still the best therapeutic option for the treatment of streptococcal infection and secondary prophylaxis, due to its efficacy and low cost.
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Best Practice & Research in Clinical Rheumatology. London: Bailliere Tindall, v. 16, n. 3, p. 481-494, 2002.