The brain decade in debate: V-neurobiology of depression

The brain decade in debate: V-neurobiology of depression

Author Barros, HMT Google Scholar
Calil, H. M. Google Scholar
Guimaraes, F. S. Google Scholar
Soares, J. C. Google Scholar
Andreatini, R. Google Scholar
Institution Univ Fed Parana
Univ Pittsburgh
Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Fundacao Fac Ciencias Porto Alegre
Abstract This paper is a transcription of a virtual symposium on the neurobiology of depression, which was organized by the Brazilian Society for Neuroscience and Behavior (SBNeC). There is a consensus that the monoaminergic theory is still valid, but its initial formulation suffered several modifications to explain more recent findings. Moreover, it is naive to suppose that depression has only one substratum and probably various neurotransmitter systems should be involved. Although nowadays the focus is mainly put on the serotonin (5-HT) system, there are several evidences suggesting an important role for other systems. It is expected that neuroimaging research with more specific tracers will give important information on this subject. the hormonal modulation is another important aspect of this picture, particularly in relation to the gender differences observed in depression. the neurobiological relationship between mania and depression states is also discussed. the intracellular transduction mechanisms are a growing field in depression research, representing the central focus of the molecular theory of depression, and it is indicated as the most fruitful theory to the development of really new drugs to treat depression. (C) 2001 Elsevier Science Inc. All rights reserved.
Keywords depression
hormones
intracellular mechanisms
noradrenaline
serotonin
Language English
Date 2002-04-01
Published in Progress in Neuro-psychopharmacology & Biological Psychiatry. Oxford: Pergamon-Elsevier B.V., v. 26, n. 3, p. 613-617, 2002.
ISSN 0278-5846 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 613-617
Origin http://dx.doi.org/10.1016/S0278-5846(01)00260-3
Access rights Closed access
Type Editorial
Web of Science ID WOS:000174698300029
URI http://repositorio.unifesp.br/handle/11600/26817

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