Heteropterys aphrodisiaca (extract BST0298): a Brazilian plant that improves memory in aged rats

Heteropterys aphrodisiaca (extract BST0298): a Brazilian plant that improves memory in aged rats

Author Galvao, SMP Google Scholar
Marques, L. C. Google Scholar
Oliveira, MGM Google Scholar
Carlini, E. A. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Literature report is lacking on pharmacological studies of the plant Heteropterys aphrodisiaca, endemic to the scrublands of Brazil. the present study was carried out to investigate the effects of oral dosing with extract BST0298 from this plant, on learning and on memory, in young (3-6-month-old) and aged (20-28-month-old) rats. the aged animals presented significant memory deficits in both the passive avoidance and T-maze left/right discrimination tests. Treatment for 7 days (50 mg/kg) or 26 days (100 mg/kg) with extract BST0298 restored the memory deficits in the passive avoidance test. However, no improvement in memory was observed after acute administration of extract BST0298 (100 mg.kg) in aged rats. An improvement in learning was also observed in the left/right discrimination test in aged rats treated for 109 days with BST0298 at a dose of 50 mg/kg. These results suggest that treatment for 7 days or more with H. aphrodisiaca improves learning and memory deficits in aged rats. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
Keywords Heteropterys aphrodisiaca
medicinal plants
aged rats
Language English
Date 2002-03-01
Published in Journal of Ethnopharmacology. Clare: Elsevier Sci Ireland Ltd, v. 79, n. 3, p. 305-311, 2002.
ISSN 0378-8741 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 305-311
Origin http://dx.doi.org/10.1016/S0378-8741(01)00402-0
Access rights Closed access
Type Article
Web of Science ID WOS:000174733800003
URI http://repositorio.unifesp.br/handle/11600/26785

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