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dc.contributor.authorHipólide, Débora Cristina [UNIFESP]
dc.contributor.authorD'Almeida, Vania [UNIFESP]
dc.contributor.authorRaymond, Roger
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.authorNobrega, J. N.
dc.date.accessioned2016-01-24T12:33:15Z
dc.date.available2016-01-24T12:33:15Z
dc.date.issued2002-02-01
dc.identifierhttp://dx.doi.org/10.1080/00207450212022
dc.identifier.citationInternational Journal of Neuroscience. Abingdon: Taylor & Francis Ltd, v. 112, n. 2, p. 155-166, 2002.
dc.identifier.issn0020-7454
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/26752
dc.description.abstractRecent indications of oxidative stress in hypothalamus of sleep deprived rats prompted us to address the possibility that sleep deprivation may induce pathological cell loss changes in brain. Indices of necrosis and apoptosis were quantified after 96 h of sleep deprivation induced by the classical platform technique in rats. Binding of the peripheral-type benzodiazepine ligand [H-3] PK 11195 to reactive astrocytes, a reliable and sensitive index of necrotic changes, was not altered in any of 14 brain regions examined. Likewise, no changes were found in mRNA levels of the apoptosis-related genes bcl-2 and bax in any of 24 brain regions examined. This was corroborated by quantitative TUNEL analyses in hypothalamus, amygdala, and cortex, which also revealed no effects in sleep deprived animals. These results are consistent with other recent evidence that sleep deprivation does not induce necrotic or apoptotic cell loss in brain. This suggests that recent findings of oxidative stress in sleep deprived brains do not result in cell loss. the possibility that sleep deprivation may result in functional deficits, or that structural changes may emerge after repeated episodes of sleep deprivation, remains to be addressed.en
dc.format.extent155-166
dc.language.isoeng
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofInternational Journal of Neuroscience
dc.rightsAcesso restrito
dc.subjectapoptosisen
dc.subjectautoradiographyen
dc.subjectbaxen
dc.subjectbcl-2en
dc.subjectgliosisen
dc.subjectin situ hybridizationen
dc.subjectneuropathologyen
dc.subjectomega(3) receptorsen
dc.subject[H-3] PK 11195en
dc.subjectTUNELen
dc.titleSleep deprivation does not affect indices of necrosis or apoptosis in rat brainen
dc.typeArtigo
dc.rights.licensehttp://journalauthors.tandf.co.uk/permissions/reusingOwnWork.asp
dc.contributor.institutionCtr Addict & Mental Hlth
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.description.affiliationCtr Addict & Mental Hlth, Neuroimaging Res Sect, Toronto, ON MST 1R8, Canada
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psychobiol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psychobiol & Pediat, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psychobiol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psychobiol & Pediat, São Paulo, Brazil
dc.identifier.doi10.1080/00207450212022
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000175942300004


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