The mitochondrial toxin 3-nitropropionic acid aggravates reserpine-induced oral dyskinesia in rats

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dc.contributor.author Calvente, PRV
dc.contributor.author Araujo, CCS
dc.contributor.author Bergamo, M.
dc.contributor.author Abilio, V. C.
dc.contributor.author D'Almeida, V
dc.contributor.author Ribeiro, RDA
dc.contributor.author Frussa, R.
dc.date.accessioned 2016-01-24T12:33:15Z
dc.date.available 2016-01-24T12:33:15Z
dc.date.issued 2002-02-01
dc.identifier http://dx.doi.org/10.1016/S0278-5846(01)00255-X
dc.identifier.citation Progress in Neuro-psychopharmacology & Biological Psychiatry. Oxford: Pergamon-Elsevier B.V., v. 26, n. 2, p. 401-405, 2002.
dc.identifier.issn 0278-5846
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/26749
dc.description.abstract The effects of a previous long-term administration of the mitochondrial toxin 3-nitropropionic acid were studied on an animal model of tardive dyskinesia, i.e., die frequency of spontaneous tongue protrusions in rats repeatedly treated with reserpine. 3-Nitropropionic acid (10 or 15 mg/kg ip, every other day for 17 days) potentiated the increase in tongue-protrusion frequency induced by reserpine (1 mg/kg, sc, every other day for 3 days) but did not modify reserpine-induced increase in immobility duration and decrease in locomotion frequency. These results support the notion that neurotoxic events are associated with the development of tardive dyskinesia. (C) 2001 Elsevier Science Inc. All rights reserved. en
dc.format.extent 401-405
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Progress in Neuro-psychopharmacology & Biological Psychiatry
dc.rights Acesso restrito
dc.subject rat en
dc.subject reserpine en
dc.subject tardive dyskinesia en
dc.subject tongue protrusion en
dc.subject 3-nitropropionic acid en
dc.title The mitochondrial toxin 3-nitropropionic acid aggravates reserpine-induced oral dyskinesia in rats en
dc.type Resenha
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Dept Farmacol
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Dept Farmacol, BR-04023970 São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Pediat, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Pediat, São Paulo, Brazil
dc.identifier.doi 10.1016/S0278-5846(01)00255-X
dc.description.source Web of Science
dc.identifier.wos WOS:000173005700028



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