Extracellular matrix components are altered in the hippocampus, cortex, and cerebrospinal fluid of patients with mesial temporal lobe epilepsy
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2002-01-01
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Perosa, Sandra Regina [UNIFESP]
Porcionatto, Marimélia Aparecida [UNIFESP]
Cukiert, A.
Martins, João Roberto Maciel [UNIFESP]
Amado, Débora [UNIFESP]
Nader, Helena Bonciani [UNIFESP]
Leite, J. P.
Naffah-Mazzacoratti, Maria da Graca [UNIFESP]
Cavalheiro, Esper Abrão [UNIFESP]
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Purpose: This work studied the profile of glycosaminoglycans (GAGs) in the hippocampus, cortex, and cerebrospinal fluid of patients with temporal lobe epilepsy (TLE).Methods: the GAGs were analyzed by agarose gel electrophoresis, enzymatic degradation, and enzyme-linked immunosorbent assay (ELISA).Results: the hippocampus of TLE patients showed increased levels of chondroitin sulfate and hyaluronic acid against normal levels of these GAGs in the neocortex and cerebrospinal fluid (CSF).Conclusions: These results suggest that these matrix components could be involved in the pathophysiology of TLE.
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Epilepsia. Malden: Blackwell Publishing Inc, v. 43, p. 159-161, 2002.