Cow's milk protein intolerance and chronic constipation in children
Naspitz, C. K.
Neto, U. F.
De Morais, M. B.
Is part ofPediatric Allergy and Immunology
MetadataShow full item record
Cow's milk protein (CMP) allergy was investigated in 25 children (age-range 3 months to 11 years) with chronic constipation. A diagnosis of constipation was made on the basis of a history of painful elimination of hard stools for at least 1 month, whether or not associated with a reduced frequency of stools or soiling. the children were evaluated using clinical parameters and the following laboratory tests: total serum immunoglobulin E (IgE); specific IgE (radioallergosorbent test [RAST]) for whole cow's milk, alpha-lactoalbumin, beta-lactoglobulin, and a food group; and skin-prick tests with whole milk, alpha-lactoalbumin, beta-lactoglobulin, and casein. Following the evaluation, the children were submitted to a CMP-free diet for a period of 4 weeks. in seven patients (28%)), constipation disappeared during the CMP-free diet and reappeared within 48-72 h following challenge with cow's milk. in two infants a rectal biopsy revealed allergic colitis and they therefore did not undergo the challenge. High serum levels of total IgE were observed in five. of the children who showed a clinical improvement (71%), a positive skin-test in two (29%), and detectable specific IgE in two (29%). These results suggest that CMP allergy or intolerance should be considered as a cause of chronic refractory constipation in children, although the underlying mechanism still require further investigation.
CitationPediatric Allergy and Immunology. Copenhagen: Blackwell Munksgaard, v. 12, n. 6, p. 339-342, 2001.
- EPM - Artigos