Show simple item record

dc.contributor.authorUehara, M. H.
dc.contributor.authorKohlmann, NEB
dc.contributor.authorZanella, M. T.
dc.contributor.authorFerreira, SRG
dc.date.accessioned2016-01-24T12:31:30Z
dc.date.available2016-01-24T12:31:30Z
dc.date.issued2001-10-01
dc.identifierhttp://dx.doi.org/10.1046/j.1463-1326.2001.00136.x
dc.identifier.citationDiabetes Obesity & Metabolism. Oxford: Blackwell Science Ltd, v. 3, n. 5, p. 319-325, 2001.
dc.identifier.issn1462-8902
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/26639
dc.description.abstractBackground: Since metformin improves insulin sensitivity, it has been indicated for patients with diabetes and hypertension, which are insulin-resistant conditions. in contrast to its well-known effects on carbohydrate metabolism, its potential for reducing blood pressure (BP) and its effect on leptin levels have been investigated less frequently.Patients and Methods: A double-blind, randomized, placebo-controlled trial was carried out with 26 overweight diabetic subjects with mild-to-moderate hypertension to assess the effects of metformin-induced glycaemic control on BP and metabolic parameters. After a 4-week placebo period, when BP was stabilized by calcium channel blockers, they received either metformin (MG) or placebo (PG) for 12 weeks.Results: Neither group showed any change in weight throughout the study. Only metformin-treated patients reduced fasting plasma glucose (8.54+1.72 to 7.54+1.33 mmol/l, p<0.05), although HbA(1c) had decreased in both groups (PG: 6.7<plus/minus>3.0 to 5.9 +/-2.6%; MG: 5.3 +/-1.5 to 4.6 +/-0.9%; p<0.05). the initial office mean BPs were similar and decreased at the end of the treatment period in both groups, reaching statistical significance only in MG (105.7<plus/minus>8.0 to 99.2 +/-9.3 mmHg, p<0.05). No difference was observed when comparing baseline and final values obtained by 24-h ambulatory BP monitoring. Metformin induced a reduction in both insulinaemia (71.0<plus/minus>62.4 to 38.0 +/- 23.0 pmol/l, p<0.05) and the insulin resistance index (3.5<plus/minus>2.7 to 1.8 +/-1.0, p<0.05). the two groups had similar baseline leptin levels which remained unchanged after treatment (PG: 16.8<plus/minus>7.9 to 21.4 +/- 14.6 mug/l; MG: 18.5 +/- 10.3 to 18.4 +/-8.9 mug/l). Dopamine levels increased significantly only in metformin-treated subjects.Conclusions: Reductions in both the insulin levels and the resistance index reinforced metformin capacity to improve peripheral sensitivity. Moreover, such benefits were not accompanied by any hypotensive effects. Since leptin levels were affected neither by metformin per se nor by the induced insulinaemia reduction, our data support the role of body weight as the major determinant of circulating leptin levels.en
dc.format.extent319-325
dc.language.isoeng
dc.publisherBlackwell Science Ltd
dc.relation.ispartofDiabetes Obesity & Metabolism
dc.rightsAcesso restrito
dc.subjectmetforminen
dc.subjecthypertensionen
dc.subjecttype 2 diabetes mellitusen
dc.subjectinsulin resistanceen
dc.subjectleptinen
dc.titleMetabolic and haemodynamic effects of metformin in patients with type 2 diabetes mellitus and hypertensionen
dc.typeArtigo
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.description.affiliationUniversidade Federal de São Paulo, Div Endocrinol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Div Nephrol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Prevent Med, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Div Endocrinol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Div Nephrol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Prevent Med, São Paulo, Brazil
dc.identifier.doi10.1046/j.1463-1326.2001.00136.x
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000171878200003


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record