Age-related changes in the N-methyl-D-aspartate receptor binding sites within the human basal ganglia

Show simple item record

dc.contributor.author Villares, J. C.
dc.contributor.author Stavale, J. N.
dc.date.accessioned 2016-01-24T12:31:29Z
dc.date.available 2016-01-24T12:31:29Z
dc.date.issued 2001-10-01
dc.identifier http://dx.doi.org/10.1006/exnr.2001.7737
dc.identifier.citation Experimental Neurology. San Diego: Academic Press Inc, v. 171, n. 2, p. 391-404, 2001.
dc.identifier.issn 0014-4886
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/26633
dc.description.abstract The present study examined the regional differences in dopamine transporter binding sites and NMDA receptor complex binding based on autoradiographic images obtained in postmortem sections of human normal brain tissues. in middle-aged control tissues, high and comparable levels of [H-3]CFT binding were observed in the caudate nucleus, putamen, and accumbens nucleus without significant alteration along the rostrocaudal axis and ventral and dorsal parts of these nuclei. in aging normal brain tissues, dopamine binding sites for [H-3]CFT were significantly reduced in the caudate nucleus, putamen, and accumbens nucleus. L-[H-3]Glutamate, [H-3]MK-801, and [H-3]glycine binding to the NMDA receptor complex was lower in aging brain tissues than in middle-aged controls. Significant correlation did occur between age and [H-3]CFT binding and between age and L-[H-3]glutamate, [H-3]MK-801, and [H-3]glycine binding sites. These results demonstrate that the basal ganglia have age-associated reductions in dopamine transporter uptake and NMDA receptors. These data support hypoactive activity of the NI MA receptor complex system with advancing age. the dopamine transporter uptake and NMDA receptors appear to be vulnerable to the aging process in the basal ganglia. (C) 2001 Academic Press. en
dc.format.extent 391-404
dc.language.iso eng
dc.publisher Academic Press Inc
dc.relation.ispartof Experimental Neurology
dc.rights Acesso restrito
dc.subject dopaminergic transporter en
dc.subject postmortem human brain en
dc.subject pallidum en
dc.subject L-[H-3]glutamate binding en
dc.subject [H-3]MK-801 binding en
dc.subject [H-3]glycine binding en
dc.title Age-related changes in the N-methyl-D-aspartate receptor binding sites within the human basal ganglia en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo, Dept Psychobiol, Aging & Neurodegenerat Dis Brain Bank Invest Lab, BR-04023062 São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Pathol, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Psychobiol, Aging & Neurodegenerat Dis Brain Bank Invest Lab, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Pathol, BR-04023062 São Paulo, Brazil
dc.identifier.doi 10.1006/exnr.2001.7737
dc.description.source Web of Science
dc.identifier.wos WOS:000171506100022



File

File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search


Browse

Statistics

My Account