Coenzyme Q(10) exogenous administration attenuates cold stress cardiac injury
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Data
2001-05-01
Autores
Murad, Neif [UNIFESP]
Takiuchi, Katia [UNIFESP]
Lopes, Antonio C. [UNIFESP]
Bonilha, André MM [UNIFESP]
Souza, Marcio M. [UNIFESP]
Demarchi, Lea Maria MF
Higuchi, Maria de Lourdes
Tucci, Paulo JF [UNIFESP]
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The influence of coenzyme Q(10) (CoQ(10)) in cold stress test (-15 degreesC for 4 hours) cardiac functional impairment was studied in isolated isovolumic heart of control rats (C; n=12) and of placebo (P; n=11) and treated rats (CoQ(10); n=10). in addition, electron microscopic evaluation of left ventricular (LV) slices (n=3 in each group) allowed us to analyze the myocardial ultrastructure. Maximal values of developed pressure (DPmax) were similarly decreased in cold stressed animals (C=129 +/-3.9 mmHg; P=106 +/-6.7 mmHg; CoQ(10)=91 +/-3.9 mmHg); however, volume-induced enhancement of pressure generation (slope of DP / volume relations: C=0.248 +/-0.0203 mmHg/mul; P=0.2831 +/-0.0187 mmHg/mul; CoQ(10)=0.2387 (0.0225 mmHg/mul; p >0.05), and the duration of systole (C=80 +/- .6 ms; P=78 +/-1.3 ms; CoQ(10) = 80 +/-2.7 ms) were not altered. Myocardial relaxation, evaluated by the relaxation constant (C=39 +/-1.9 ins; P=42 +/-3.4 ms; CoQ(10)=51 +/-6.0 ms), as well as resting stress / strain relations were unaffected by cold stress. Myocardial samples showed that pretreatment with CoQ(10) attenuates myofibrillar and mitochondrial lesions, and prevents mitochondrial fractional area increase (P: 53.11%> CoQ(10): 38.78%=C: 33.87%; p <0.005) indicating that the exogenous administration of CoQ(10) can reduce cold stress myocardial injury.
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Japanese Heart Journal. Tokyo: Japan Heart Journal, Second Dept of Internal Med, v. 42, n. 3, p. 327-338, 2001.