Coenzyme Q(10) exogenous administration attenuates cold stress cardiac injury

Coenzyme Q(10) exogenous administration attenuates cold stress cardiac injury

Author Murad, Neif Autor UNIFESP Google Scholar
Takiuchi, Katia Autor UNIFESP Google Scholar
Lopes, Antonio C. Autor UNIFESP Google Scholar
Bonilha, André MM Autor UNIFESP Google Scholar
Souza, Marcio M. Autor UNIFESP Google Scholar
Demarchi, Lea Maria MF Google Scholar
Higuchi, Maria de Lourdes Google Scholar
Tucci, Paulo JF Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Abstract The influence of coenzyme Q(10) (CoQ(10)) in cold stress test (-15 degreesC for 4 hours) cardiac functional impairment was studied in isolated isovolumic heart of control rats (C; n=12) and of placebo (P; n=11) and treated rats (CoQ(10); n=10). in addition, electron microscopic evaluation of left ventricular (LV) slices (n=3 in each group) allowed us to analyze the myocardial ultrastructure. Maximal values of developed pressure (DPmax) were similarly decreased in cold stressed animals (C=129 +/-3.9 mmHg; P=106 +/-6.7 mmHg; CoQ(10)=91 +/-3.9 mmHg); however, volume-induced enhancement of pressure generation (slope of DP / volume relations: C=0.248 +/-0.0203 mmHg/mul; P=0.2831 +/-0.0187 mmHg/mul; CoQ(10)=0.2387 (0.0225 mmHg/mul; p >0.05), and the duration of systole (C=80 +/- .6 ms; P=78 +/-1.3 ms; CoQ(10) = 80 +/-2.7 ms) were not altered. Myocardial relaxation, evaluated by the relaxation constant (C=39 +/-1.9 ins; P=42 +/-3.4 ms; CoQ(10)=51 +/-6.0 ms), as well as resting stress / strain relations were unaffected by cold stress. Myocardial samples showed that pretreatment with CoQ(10) attenuates myofibrillar and mitochondrial lesions, and prevents mitochondrial fractional area increase (P: 53.11%> CoQ(10): 38.78%=C: 33.87%; p <0.005) indicating that the exogenous administration of CoQ(10) can reduce cold stress myocardial injury.
Keywords ubiquinone
coenzyme Q(10)
cold stress test
systolic function
diastolic
function
Language English
Date 2001-05-01
Published in Japanese Heart Journal. Tokyo: Japan Heart Journal, Second Dept of Internal Med, v. 42, n. 3, p. 327-338, 2001.
ISSN 0021-4868 (Sherpa/Romeo, impact factor)
Publisher Japan Heart Journal, Second Dept of Internal Med
Extent 327-338
Origin http://dx.doi.org/10.1536/jhj.42.327
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000171471700007
URI http://repositorio.unifesp.br/handle/11600/26537

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