Effects of short-term glucocorticoid deprivation on growth hormone (GH) response to GH-releasing peptide-6: Studies in normal men and in patients with adrenal insufficiency

Effects of short-term glucocorticoid deprivation on growth hormone (GH) response to GH-releasing peptide-6: Studies in normal men and in patients with adrenal insufficiency

Author Pinto, Ana Claudia de Assis Rocha Autor UNIFESP Google Scholar
Dias-da-Silva, Magnus Régios Autor UNIFESP Google Scholar
Martins, Manoel R. Autor UNIFESP Google Scholar
Brunner, Elisa Autor UNIFESP Google Scholar
Lengyel, Ana Maria Judith Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract There are no data in the literature about the effects of glucocorticoid deprivation on GH-releasing peptide-g (GHRP-6)-induced GH release. the aims of this study were to evaluate GH responsiveness to GHRP-6 1) after metyrapone administration in normal men, and 2) in patients with chronic hypocortisolism after glucocorticoid withdrawal for 72 h. in normal subjects, metyrapone ingestion did not alter significantly GH responsiveness to GHRP-6 [n = 8; peak, 39.3 +/- 7.1 mu g/L; area under the curve (AUC), 1958.8 +/- 445.7 mu g/min.L; mean +/- SE] compared to placebo (n = 8; peak, 21.9 +/- 4.5; AUG, 1131.0 +/- 229.6). in patients with chronic hypocortisolism (n = 8), GH responses to GHRP-6 were similar both during replacement therapy (peak, 11.8 +/- 3.9; AUG, 563.2 +/- 208.7) and after withdrawal of prednisone (peak, 14.4 +/-: 4.5; AUG, 695.6 +/- 272.9) and did not differ from those in controls. interestingly after glucocorticoid withdrawal, GH responsiveness to GHRP-6 in patients with chronic hypocortisolism was significantly lower than that in normal subjects pretreated with metyrapone. Our data suggest that short term glucocorticoid deprivation does not have a major impact on GHRP-6-dependent GH-releasing mechanisms. However, in long standing hypocortisolism, subtle changes in GHRP-6 secretory pathways may be present.
Language English
Date 2000-04-01
Published in Journal of Clinical Endocrinology & Metabolism. Chevy Chase: Endocrine Soc, v. 85, n. 4, p. 1540-1544, 2000.
ISSN 0021-972X (Sherpa/Romeo, impact factor)
Publisher Endocrine Soc
Extent 1540-1544
Origin http://dx.doi.org/10.1210/jcem.85.4.6536
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000088387200030
URI http://repositorio.unifesp.br/handle/11600/26277

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