Evaluation of the longitudinal musculature of segments of the distal colon interposed following extended jejunum-ileum resection

Evaluation of the longitudinal musculature of segments of the distal colon interposed following extended jejunum-ileum resection

Author Taha, M. O. Google Scholar
Ribeiro, MAF Google Scholar
Gomes, P. D. Google Scholar
Frasson, E. M. Google Scholar
Plapler, H. Google Scholar
Ferreira, R. Google Scholar
Lapa, A. J. Google Scholar
Soucar, C. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Several morbid conditions may necessitate extensive intestinal resection, leading to short-bower syndrome. When clinical treatment becomes inefficient, a surgical approach is necessary. Distal colon interposition is one of the viable techniques. the interposition of colon segments between remnants of the small bower improved lifestyle, increased transit time, and diminished diarrhea. the aim of this study is to observe the longitudinal muscular contractions after distal colon interposition. Sixteen male Wistar rats (EPM-1) were submitted to an 80% small bowel resection associated with a partial colectomy of the distal colon immediately after the bifurcation of the middle colic artery followed by a 3-cm isoperistaltic distal colon interposition. After 70 days, the animals were submitted to euthanasia and segments of the jejunum, ileum, remnant colon, and interposed colon were prepared for pharmacological tests. the isometric contractions were measured by a poligraph. After 30 minutes, the dose/effect curves were obtained for both metacholine and barium chloride stimulation through the extraluminal surface (serosa). After this period, we observed a significant increase in the length, diameter, and thickness of the intestinal wall. Regarding the sensibility (pD(2)), no difference was found (interposed colon = 7.21 +/- 0.2; remnant colon = 7.65 +/- 0.1; remnant jejunum 7.46 +/- 0.1, and remnant ileum 7.57 +/- 0.1), even though the animals were submitted to different procedures. in relation to the maximal effect (E-max), the longitudinal muscle contraction responses (interposed colon = 11.79 +/- 0.1; remnant jejunum = 15.42 +/- 0.2; and remnant ileum = 11.48 +/- 0.2) were lower than those of the remnant colon (E-max = 22.42 +/- 0.1). This means that there was a possible adaptation of colonic segments to their new location. (C) 1999 Wiley-Liss, Inc.
Language English
Date 1999-01-01
Published in Microsurgery. New York: Wiley-liss, v. 19, n. 7, p. 306-310, 1999.
ISSN 0738-1085 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 306-310
Origin http://dx.doi.org/10.1002/(SICI)1098-2752(1999)19:7<306
Access rights Closed access
Type Article
Web of Science ID WOS:000084231500002
URI http://repositorio.unifesp.br/handle/11600/26003

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