Dietary magnesium improves endothelial dependent relaxation of balloon injured arteries in rats

Dietary magnesium improves endothelial dependent relaxation of balloon injured arteries in rats

Author Fonseca, Francisco Antonio Helfenstein Autor UNIFESP Google Scholar
Paiva, Therezinha Bandiera Autor UNIFESP Google Scholar
Silva, Eneida de Gusmão Autor UNIFESP Google Scholar
Ihara, Silvia Saiuli Miki Autor UNIFESP Google Scholar
Kasinski, Nelson Autor UNIFESP Google Scholar
Martinez, Tânia Leme da Rocha Autor UNIFESP Google Scholar
Martinez Filho, Eulogio Emilio Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract The purpose of the present study was to examine the importance of magnesium in endothelial function after arterial balloon injury. Male Wistar rats were fed normal, high or low concentrations of magnesium. Three weeks later the animals underwent endothelial injury of the thoracic aorta by a balloon catheter or a sham operation. Biochemical, histological and endothelial function analysis were performed 15 days after the surgical treatment. the animals fed a low magnesium diet presented the lowest level of serum magnesium and the highest ionized blood calcium levels. Histomorphometric analysis revealed no differences among groups neither regarding the magnitude of intimal thickening nor the recovery of endothelial coverage. However, when vasoreactivity responses were compared in the balloon-injured group, those animals fed a high magnesium diet had the better endothelium-dependent vascular relaxation. in conclusion, a higher magnesium level in the diet was beneficial to vessels that underwent endothelial injury by balloon catheter. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.
Keywords magnesium
endothelium-derived relaxing factor
Language English
Date 1998-08-01
Published in Atherosclerosis. Clare: Elsevier Sci Ireland Ltd, v. 139, n. 2, p. 237-242, 1998.
ISSN 0021-9150 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 237-242
Access rights Closed access
Type Article
Web of Science ID WOS:000075128000004

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