Show simple item record

dc.contributor.authorBrasil, Luiz A. [UNIFESP]
dc.contributor.authorGomes, Walter J. [UNIFESP]
dc.contributor.authorSalomão, Reinaldo [UNIFESP]
dc.contributor.authorBuffolo, Enio [UNIFESP]
dc.date.accessioned2016-01-24T12:30:36Z
dc.date.available2016-01-24T12:30:36Z
dc.date.issued1998-07-01
dc.identifierhttp://dx.doi.org/10.1016/S0003-4975(98)00181-7
dc.identifier.citationAnnals of Thoracic Surgery. New York: Elsevier B.V., v. 66, n. 1, p. 56-59, 1998.
dc.identifier.issn0003-4975
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/25915
dc.description.abstractBackground. Tumor necrosis factor-alpha has been implicated in complications seen after cardiac operations with cardiopulmonary bypass. the release of tumor necrosis factor-alpha and its possible effects were studied in patients undergoing coronary artery bypass grafting with and without cardiopulmonary bypass.Methods. Twenty patients were studied, 10 with (group 1) and 10 without cardiopulmonary bypass (group 2). Serial blood samples were obtained before, during and up to 48 hours after operation. Circulating tumor necrosis factor-alpha levels, leukocyte counts, and erythrocyte sedimentation rates were measured. Hemodynamic variables (blood pressure and heart rate), temperature, orotracheal intubation time, postoperative bleeding, and inotropic drug requirements were compared.Results, Serum levels of tumor necrosis factor-alpha were detected in 6 patients (60%) in group 1 and none in group 2. the patients in group 1 had more hypotension than those in group 2 (7.4 +/- 1.0 mm Hg versus 8.5 +/- 0.7 mm Hg), required more inotropic drugs (8 patients versus 1 patient), and had a higher heart rate (114 +/- 8 beats per minute versus 98 +/- 10 beats per minute), a higher temperature (37.1 degrees +/- 0.5 degrees C versus 36.6 degrees +/- 0.3 degrees C), increased postoperative bleeding (820 +/- 120 mL versus 360 +/- 84 mL), a longer orotracheal intubation time (13.6 +/- 2.2 hours versus 9.3 +/- 1.4 hours), and a more pronounced leukocytosis.Conclusions. Cardiopulmonary bypass induces the whole-body inflammatory response through the release of tumor necrosis factor ct, resulting in adverse systemic effects, (Ann Thorac Surg 1998;66:56-9) (C) 1998 by the Society of Thoracic Surgeons.en
dc.format.extent56-59
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofAnnals of Thoracic Surgery
dc.rightsAcesso aberto
dc.titleInflammatory response after myocardial revascularization with or without cardiopulmonary bypassen
dc.typeArtigo
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, Discipline Cardiovasc Surg, BR-04023900 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, Discipline Infect Dis, BR-04023900 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, São Paulo Hosp, BR-04023900 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, Discipline Cardiovasc Surg, BR-04023900 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, Discipline Infect Dis, BR-04023900 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, São Paulo Hosp, BR-04023900 São Paulo, Brazil
dc.identifier.doi10.1016/S0003-4975(98)00181-7
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000074992000014


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record