Moclobemide effects on prolactin plasma levels in healthy individuals: the hormonal increase induced by a single dose is maintained during a 4-week period of drug intake

Moclobemide effects on prolactin plasma levels in healthy individuals: the hormonal increase induced by a single dose is maintained during a 4-week period of drug intake

Author Juruena, M. F. Google Scholar
Pires, MLN Google Scholar
Calil, H. M. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Neuroendocrine challenge studies are frequently used to study the pathophysiology of psychiatric illnesses and the effects of psychotropic drug treatment on brain monoamine function. Moclobemide, a reversible inhibitor of monoamine oxidase, with predominant effects on the A-type of the enzyme, was administered to 15 healthy men. Seven out of the 15 also received single blind placebo a week before the moclobemide. the individuals received moclobemide as a single dose (150 mg), followed by doses of 150 mg three times a day, during a 4-week period. Plasma prolactin was measured in the morning over a 150-min period, following the single dose, and then at the end of weeks 1, 2 and 4 of moclobemide intake. the present data show an acute and transitory increase of plasma prolactin levels after the single dose, and also during the long-term moclobemide administration. It might indicate that steady-state moclobemide levels, during the long-term drug administration, were low and thus large fluctuations of drug levels occurred between doses. Thus, it is suggested that larger doses or administering smaller doses more frequently, or both, may induce hyperprolactinaemia with clinical consequences.
Keywords healthy individuals
moclobemide
monoamines
monoamine oxidase type A inhibitor
prolactin
Language English
Date 1997-11-01
Published in International Clinical Psychopharmacology. Philadelphia: Lippincott Williams & Wilkins, v. 12, n. 6, p. 317-321, 1997.
ISSN 0268-1315 (Sherpa/Romeo, impact factor)
Publisher Lippincott Williams & Wilkins
Extent 317-321
Origin http://dx.doi.org/10.1097/00004850-199711000-00004
Access rights Closed access
Type Article
Web of Science ID WOS:000071359000004
URI http://repositorio.unifesp.br/handle/11600/25808

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