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dc.contributor.authorDAlmeida, V
dc.contributor.authorHipolide, D. C.
dc.contributor.authorAzzalis, L. A.
dc.contributor.authorLobo, L. L.
dc.contributor.authorJunqueira, VBC
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.identifier.citationNeuroscience Letters. Clare: Elsevier Sci Ireland Ltd, v. 235, n. 1-2, p. 25-28, 1997.
dc.description.abstractParadoxical sleep deprivation was performed on rats using platform technique to investigate the oxidative process associated with it. Levels of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), total glutathione (GSH) and malondialdehyde production were measured in brain of rats under control conditions (C) and those on single large platforms (SLP), multiple large platforms (MLP), single small platforms (SSP) and multiple small platforms (MSP) groups. SOD, CAT and GPx brain activity and malondialdehyde production were not modified by any of the procedures. Brain GSH, however, was significantly reduced in both SSP and SLP groups. These results suggest that paradoxical sleep deprivation per se is not associated with oxidative damage. the observed alterations could be attributed to factors such as immobilization and social isolation present in the single platform techniques. (C) 1997 Elsevier Science Ireland Ltd.en
dc.publisherElsevier B.V.
dc.relation.ispartofNeuroscience Letters
dc.rightsAcesso restrito
dc.subjectparadoxical sleep deprivationen
dc.subjectoxidative stressen
dc.subjectantioxidant defenseen
dc.subjectlipid peroxidationen
dc.titleAbsence of oxidative stress following paradoxical sleep deprivation in ratsen
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.description.affiliationUniversidade Federal de São Paulo,ESCOLA PAULISTA MED,DEPT PSYCHOBIOL,BR-04023062 São Paulo,BRAZIL
dc.description.affiliationUNIV São Paulo,DEPT BIOCHEM,São Paulo,BRAZIL
dc.description.affiliationUnifespUniversidade Federal de São Paulo,ESCOLA PAULISTA MED,DEPT PSYCHOBIOL,BR-04023062 São Paulo,BRAZIL
dc.description.sourceWeb of Science

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