PROFILE of PROSTAGLANDIN LEVELS in the RAT HIPPOCAMPUS in PILOCARPINE MODEL of EPILEPSY

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1995-12-01
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Naffah-mazzacoratti, M. G.
Bellissimo, M. I.
Cavalheiro, E. A.
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Pilocarpine (PILO) administered to rats acutely induces status epilepticus (acute period), which is followed by a transient seizure-free period (silent period), and finally by a chronic phase of spontaneous recurrent seizures (chronic period, SRS) that lasts for the rest of animal's life. Hippocampal neurochemical changes following PILO administration include alteration in monoamines and amino acids content during all phases of this epilepsy model. the present work was delineated to study the content df prostaglandins (PG) levels in hippocampus during the three phases of this model. the levels of PG E(2), PG F-2 alpha and PG D-2 were measured by radioimmunoassay 1 h after PILO, 5 h after PILO, during the silent period, and interictally into the chronic period. the results show, in hippocampus of rats, increase of PG F-2 alpha and PG D-2 during status epilepticus, increase of PG D-2 during the silent period and increase of PG E(2) and PG D-2 during the chronic phase, when compared with control group. These changes match previously reported alteration in monoamines and amino acid levels, showing that altered neurotransmission is accompanied by changes in second messengers and enzyme activity related to PG production during all phases of this epilepsy model.
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Neurochemistry International. Oxford: Pergamon-Elsevier B.V., v. 27, n. 6, p. 461-466, 1995.
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