A COMPARATIVE-STUDY ON the MECHANISM of the ANTICOAGULANT ACTION of MOLLUSK and MAMMALIAN HEPARINS

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dc.contributor.author Paiva, J. F.
dc.contributor.author Santos, E. A.
dc.contributor.author Jeske, W.
dc.contributor.author Fareed, J.
dc.contributor.author Nader, H. B.
dc.contributor.author Dietrich, C. P.
dc.date.accessioned 2016-01-24T11:40:25Z
dc.date.available 2016-01-24T11:40:25Z
dc.date.issued 1995-07-01
dc.identifier http://dx.doi.org/10.1016/0300-9629(94)00021-K
dc.identifier.citation Comparative Biochemistry and Physiology A-physiology. Oxford: Pergamon-Elsevier B.V., v. 111, n. 3, p. 495-499, 1995.
dc.identifier.issn 0300-9629
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/25511
dc.description.abstract The anticlotting activities on some steps of the coagulation cascade of mollusc and mammalian heparins were studied. AT III-high affinity heparin is a more potent inhibitor than unfractionated heparin and mollusc heparin in the intrinsic and extrinsic pathways of thrombin and factor Xa generation. Mollusan heparin has about the same activity as the AT III high affinity-heparin on the inhibition of factor Xa and thrombin in the presence of antithrombin III and four times more inhibitory activity than unfractionated heparin on the heparin cofactor II mediated inhibition of thrombin. en
dc.format.extent 495-499
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Comparative Biochemistry and Physiology A-physiology
dc.rights Acesso restrito
dc.subject MOLLUSK HEPARIN en
dc.subject COAGULATION FACTORS en
dc.subject ANTITHROMBIN III ACTION en
dc.subject HEPARIN COFACTOR II en
dc.subject ACTION in the COAGULATION CASCADE en
dc.subject INTRINSIC and EXTRINSIC MEDIATED INHIBITION of THROMBIN en
dc.title A COMPARATIVE-STUDY ON the MECHANISM of the ANTICOAGULANT ACTION of MOLLUSK and MAMMALIAN HEPARINS en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation ESCOLA PAULISTA MED,DEPT BIOQUIM,BR-04044020 São Paulo,BRAZIL
dc.description.affiliationUnifesp ESCOLA PAULISTA MED,DEPT BIOQUIM,BR-04044020 São Paulo,BRAZIL
dc.identifier.doi 10.1016/0300-9629(94)00021-K
dc.description.source Web of Science
dc.identifier.wos WOS:A1995RF80500021



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