A COMPARATIVE-STUDY ON the MECHANISM of the ANTICOAGULANT ACTION of MOLLUSK and MAMMALIAN HEPARINS

A COMPARATIVE-STUDY ON the MECHANISM of the ANTICOAGULANT ACTION of MOLLUSK and MAMMALIAN HEPARINS

Author Paiva, J. F. Google Scholar
Santos, E. A. Google Scholar
Jeske, W. Google Scholar
Fareed, J. Google Scholar
Nader, H. B. Google Scholar
Dietrich, C. P. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract The anticlotting activities on some steps of the coagulation cascade of mollusc and mammalian heparins were studied. AT III-high affinity heparin is a more potent inhibitor than unfractionated heparin and mollusc heparin in the intrinsic and extrinsic pathways of thrombin and factor Xa generation. Mollusan heparin has about the same activity as the AT III high affinity-heparin on the inhibition of factor Xa and thrombin in the presence of antithrombin III and four times more inhibitory activity than unfractionated heparin on the heparin cofactor II mediated inhibition of thrombin.
Keywords MOLLUSK HEPARIN
COAGULATION FACTORS
ANTITHROMBIN III ACTION
HEPARIN COFACTOR II
ACTION in the COAGULATION CASCADE
INTRINSIC and EXTRINSIC MEDIATED INHIBITION of THROMBIN
Language English
Date 1995-07-01
Published in Comparative Biochemistry and Physiology A-physiology. Oxford: Pergamon-Elsevier B.V., v. 111, n. 3, p. 495-499, 1995.
ISSN 0300-9629 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 495-499
Origin http://dx.doi.org/10.1016/0300-9629(94)00021-K
Access rights Closed access
Type Article
Web of Science ID WOS:A1995RF80500021
URI http://repositorio.unifesp.br/handle/11600/25511

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