EFFECTS of MONOSIALOGANGLIOSIDE ON DOPAMINERGIC SUPERSENSITIVITY

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Data
1995-05-19
Autores
Vital, MABF
Frussafilho, R.
Palermoneto, J.
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The effects of monosialoganglioside (GM(1)) treatment on dopaminergic supersensitivity induced by long-term haloperidol administration were studied; both general activity of rats observed in an open-field and apomorphine-induced stereotyped behavior were used as experimental parameters. GM(1) per se (5.0 mg/kg, twice daily, for 30 days) did not modify rat behavior, but when given in combination with haloperidol (1.0 mg/kg, twice daily, for 30 days) it increased neuroleptic withdrawal symptoms as detected in both models. When GM(1) (5.0 mg/kg, twice daily) was administered after abrupt withdrawal from haloperidol (1.0 mg/kg, twice daily, for 30 days), it attenuated the increases in both general activity of rats observed in the open-field and apomorphine-induced stereotyped behavior. These results suggest that GM(1) may affect synaptic plasticity, facilitating the induction of the adaptative changes in receptor function (up and down-regulation), following long-term haloperidol treatment and withdrawal.
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Life Sciences. Oxford: Pergamon-Elsevier B.V., v. 56, n. 26, p. 2299-2307, 1995.