LOSS of STRIATAL HIGH-AFFINITY NGF BINDING-SITES in PROGRESSIVE SUPRANUCLEAR PALSY BUT NOT in PARKINSONS-DISEASE

Date
1994-11-21Author
Villares, J.
Strada, O.
Faucheux, B.
Javoyagid, F.
Agid, Y.
Hirsch, E. C.
Type
ArtigoISSN
0304-3940Is part of
Neuroscience LettersDOI
10.1016/0304-3940(94)90205-4Metadata
Show full item recordAbstract
I-125-Nerve growth factor (NGF) binding sites were analyzed by autoradiography in the striatum of 3 central subjects, 3 patients with Parkinson's disease and 3 patients with progressive supranuclear palsy. A high level of I-125-NGF binding was observed (0.3-0.4 fmol/mg of tissue equivalent) in the striatum and the nucleus basalis of Meynert of control patients. Pockets of lower I-125-NGF binding corresponding to acetylcholinesterase-poor striosomes were detected in the striatum of control subjects and patients with Parkinson's disease or progressive supranuclear palsy. When compared to controls, the density of I-125-NGF binding sites was reduced by 30% in the striatum of patients with progressive supranuclear palsy but not reduced in that of patients with Parkinson's disease. I-125-NGF binding was not significantly decreased in the nucleus basalis of Meynert in either diseases. Since NGF receptors are thought to be localized on cholinergic neurons in the striatum, the decrease in NGF binding is compatible with the loss of cholinergic neurons reported in the striatum from PSP patients.
Citation
Neuroscience Letters. Clare: Elsevier Sci Publ Ireland Ltd, v. 182, n. 1, p. 59-62, 1994.Keywords
CHOLINERGIC NEURONNERVE GROWTH FACTOR
PARKINSONS DISEASE
PROGRESSIVE SUPRANUCLEAR PALSY
AUTORADIOGRAPHY
Collections
- EPM - Artigos [17701]