TESTOSTERONE CONTROL of END-PLATE and NON-END-PLATE ACETYLCHOLINESTERASE in the RAT LEVATOR ANI MUSCLE

TESTOSTERONE CONTROL of END-PLATE and NON-END-PLATE ACETYLCHOLINESTERASE in the RAT LEVATOR ANI MUSCLE

Author Godinho, R. O. Google Scholar
Souccar, C. Google Scholar
Lapa, A. J. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract The time course of effects of castration (5-60 days) and testosterone treatment (15-60 days) of adult male rats were examined on the endplate (+EP) and non-endplate (-EP) acetylcholinesterase (AChE) of the androgen-dependent levator ani (LA) muscle. the thiocholine method was used to determine the enzyme activity. Castration caused LA muscle atrophy within 5 days but reduced the -EP and +EP AChE after 10 and 20 days, respectively. Following 30 days castration -EP and +EP AChE reached respectively 41% and 35% of control activity. Testosterone retrieval restored the control values of both muscle weight and total AChE after 15 and 60 days, respectively. Recovery of the +EP AChE preceded that of -EP AChE by 30 days. the results showed that in the rat LA muscle, +EP and -EP AChE depend on a continuous testosterone regulation that predominates at +EP region spreading thereafter to -EP region. Those data suggest a hormone regulation of AChE exerted indirectly through the synthesis and release of neurotrophic substances.
Keywords ACETYLCHOLINESTERASE
LEVATOR ANI MUSCLE
TESTOSTERONE
SKELETAL MUSCLE
NEUROMUSCULAR JUNCTION
Language English
Date 1994-06-01
Published in Neurochemical Research. New York: Plenum Publ Corp, v. 19, n. 6, p. 657-663, 1994.
ISSN 0364-3190 (Sherpa/Romeo, impact factor)
Publisher Plenum Publ Corp
Extent 657-663
Origin http://dx.doi.org/10.1007/BF00967703
Access rights Closed access
Type Article
Web of Science ID WOS:A1994NK71000003
URI http://repositorio.unifesp.br/handle/11600/25411

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