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dc.contributor.authorNunes, G. P.
dc.contributor.authorTufik, S.
dc.contributor.authorNobrega, J. N.
dc.date.accessioned2016-01-24T11:40:18Z
dc.date.available2016-01-24T11:40:18Z
dc.date.issued1994-05-09
dc.identifierhttp://dx.doi.org/10.1016/0006-8993(94)91658-6
dc.identifier.citationBrain Research. Amsterdam: Elsevier B.V., v. 645, n. 1-2, p. 247-252, 1994.
dc.identifier.issn0006-8993
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/25408
dc.description.abstractPrevious work demonstrated that paradoxical sleep deprivation (PSD) leads to a decrease in yawning behavior elicited by cholinergic agonists, suggesting that a downregulation of cholinergic muscarinic receptors may occur after PSD. More recent work using intracerebral injections of muscarinic agonists has suggested a critical role for M2 receptors in paradoxical sleep. in this study [H-3]AF-DX 384 was used to investigate the effects of PSD on M2-type cholinergic receptors throughout the brain using quantitative autoradiography. After 96 h of paradoxical sleep deprivation, [3H]AF-DX 384 binding was generally reduced throughout the brain, and significantly so in the olfactory tubercle (-20%), n. accumbens (-23%), frontal caudate-putamen (-16%), islands of Callejas (-20%), piriform cortex (-24%), lateral (-26%) and medial (-24%) septum, anteromedial (-19%), ventrolateral (-22%), and lateral geniculate (-15%) nuclei of thalamus, deep layers of the superior colliculus (-15%), entorhinal cortex (-12%) and subiculum (-23%). [H-3]AF-DX 384 binding was reduced in pontine structures, but not to a higher degree than in other brain areas. the observed downregulation of M2-type muscarinic receptors after PSD may be causally related to the previously reported decrease in cholinergically induced behaviors after PSD.en
dc.format.extent247-252
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofBrain Research
dc.rightsAcesso restrito
dc.subjectPARADOXICAL SLEEP DEPRIVATIONen
dc.subjectRATen
dc.subjectBRAIN MUSCARINIC M2 RECEPTORen
dc.subjectACETYLCHOLINEen
dc.subject[H-3] AF-DX 384en
dc.titleDECREASED MUSCARINIC RECEPTOR-BINDING in RAT-BRAIN AFTER PARADOXICAL SLEEP-DEPRIVATION - AN AUTORADIOGRAPHIC STUDYen
dc.typeArtigo
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institutionCLARKE INST PSYCHIAT
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.description.affiliationCLARKE INST PSYCHIAT, NEUROIMAGING RES STN, TORONTO M5T 1R8, ON, CANADA
dc.description.affiliationESCOLA PAULISTA MED, DEPT PSICOBIOL, BR-04023 São Paulo, BRAZIL
dc.description.affiliationUnifespESCOLA PAULISTA MED, DEPT PSICOBIOL, BR-04023 São Paulo, BRAZIL
dc.identifier.doi10.1016/0006-8993(94)91658-6
dc.description.sourceWeb of Science
dc.identifier.wosWOS:A1994NK54000028


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