THE CAUDAL VENTROLATERAL MEDULLA IS A SOURCE of TONIC SYMPATHOINHIBITION

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1993-09-03
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Cravo, S. L.
Morrison, S. F.
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The caudal ventrolateral medulla (CVLM) contains neurons that are essential for the elaboration of the sympathoinhibitory effects of baroreceptor afferent stimulation. To determine if neurons in the CVLM also mediate a tonic inhibition of sympathetic nerve activity (SNA), we examined the effects of lesioning CVLM neurons in baroreceptor-denervated rats. the sustained increases in both arterial pressure (AP; 40 mmHg) and splanchnic SNA (200%) indicate that the discharge of neurons in the CVLM maintains a tonic sympathoinhibition that contributes significantly to the maintenance of normotensive levels of SNA and AP.
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Brain Research. Amsterdam: Elsevier B.V., v. 621, n. 1, p. 133-136, 1993.
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