COMPARISON BETWEEN CLEARANCE RATES of PLASMA KALLIKREIN and of PLASMA KALLIKREIN-ALPHA-MACROGLOBULIN COMPLEXES BY the LIVER

Abstract

1. Alpha-Macroglobulins (alphaMs) were isolated from the serum of injured rats through a two-stage method: gel filtration and ultracentrifugation.2. the clearance rates of rat plasma kallikrein (RPK) and alphaMs-RPK complexes were compared in an isolated rat liver perfusion system: the alphaMs-RPK complexes are cleared at a much slower rate (half-life ranging from 24 to > 120 min) than does RPK itself (half-life ranging from 13 to 18 min).