IMMUNOHISTOCHEMICAL EVALUATION of UVEAL MELANOCYTIC TUMORS - EXPRESSION of HMB-45, S-100 PROTEIN, and NEURON-SPECIFIC ENOLASE

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1991-08-15
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Burnier Junior, Miguel Noel [UNIFESP]
Mclean, I. W.
Gamel, J. W.
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The authors compared the immunohistochemical reactivity of 13 uveal nevi and 20 uveal melanomas for HMB-45, S-100 protein, and neuron-specific enolase (NSE) in formalin-fixed, paraffin-embedded sections. All 33 of the lesions were positive for HMB-45. the false-negative rates for S-100 protein and NSE were 21% and 18%, respectively. If only strongly positive reactions were considered, more than 50% of the tumors would be interpreted as negative for S-100 protein and NSE. Nevi stained with less intensity than melanomas using all three antibodies. the expression of HMB-45 appeared to be greater in active nevi than in inactive nevi. There was a weak association between S-100 protein reactivity and the ability of the uveal melanomas to metastasize (P = 0.1); however, the standard deviation of nucleolar area was a much better predictor (P = 0.02). These results indicate that pathologists will find HMB-45 to be a useful tool in differentiating uveal melanoma from nonmelanocytic tumors.
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Cancer. New York: Wiley-liss, v. 68, n. 4, p. 809-814, 1991.
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