Efeito do exercício físico na doença de Parkinson: aspectos bioquímicos, cognitivos e comportamentais
Data
2013
Autores
Tanaka, Katia 
Orientadores
Galduróz, José Carlos Fernandes
Tipo
Tese de doutorado
Título da Revista
ISSN da Revista
Título de Volume
Resumo
A doenca de Parkinson (DP) e uma patologia neurodegenerativa, caracterizada pelo comprometimento motor, devido a degeneracao dos neuronios dopaminergicos na via nigro-estriatal. A forma de tratamento mais utilizada e por meio da administracao de levodopa (L-Dopa). Porem, o uso continuo desta substancia, a longo prazo, pode acarretar alteracoes bioquimicas, cognitivas e comportamentais. Uma possivel forma de amenizar esses problemas seria pela pratica de exercicio fisico. Desta forma, o objetivo do presente estudo foi analisar os efeitos do exercicio fisico sobre os aspectos bioquimicos, cognitivos e comportamentais de individuos com a DP. Participaram deste estudo 39 pessoas, sendo 11 do grupo controle (GC) u neurologicamente saudaveis que nao praticou exercicio fisico; 13 do grupo controle com DP (GCP) u nao participou do programa de exercicio fisico; e 15 do grupo treinado com DP (GTP) u participou de um programa de exercicio fisico multimodal, durante dois meses, tres vezes por semana, uma hora por sessao. Todos foram avaliados, pre e pos-intervencao, quanto aos niveis de atividade fisica, progesterona, estradiol, homocisteina, desidrogenase lactica, fator de crescimento semelhante a insulina (IGF-1) e glutationa peroxidase. Foram avaliadas tambem as funcoes cognitivas (testes de memoria, funcoes executivas e atencao). As variaveis comportamentais foram: ansiedade, sintomas depressivos e estresse. Apos as coletas dos dados foram comparados os resultados entre os grupos por meio do teste General Linear Model (GLM). Os resultados apontaram interacao significativa entre os grupos e momentos apenas em homocisteina (F=4,20; p=0,02) e IGF-1 (F=6,97; p<0,01). Nao foram encontradas interacoes significativas entre grupos e momentos nas demais variaveis bioquimicas (p>0,05), bem como nas avaliacoes cognitivas e comportamentais (p>0,05). Estes resultados sugerem que dois meses de exercicio fisico parece ser o suficiente para regular os niveis de homocisteina e aumentar os niveis sericos de IGF-1 de pessoas com DP
Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor impairment due to degeneration of dopaminergic neurons in the nigrostriatal pathway. The most widely used form of treatment is the administration of levodopa (L-Dopa). However, the continued use of this substance in the long term can lead to biochemical, cognitive and behavioral changes. One possible way to alleviate these problems would be physical exercise. Thus, the obje ctive of this study was to analyze the effects of physical exercise on the biochemical, cognitive and behavioral aspects of people with PD. The study included 39 individuals, out of which 11 in a control group (CG) were neurologically healthy and did not practiced physical exercise; 13 in the other control group with DP (CGP) and were not involved in the exercise program; and 15 in the trained group with PD (TGP) who participated in a multimodal exercise program during two months, three times a week, one hour per session. All subjects were evaluated pre-and post-intervention regarding the levels of physical activity, progesterone, estradiol, homocysteine, lactic dehydrogenase, insulin-like growth factor (IGF-1) and glutathione peroxidase. We also evaluated cognitive functions (memory, attention and executive function s). The behavioral variables were anxiety, depressive symptoms and stress. After we collected the data, we compare the results between groups by General Linear Model (GLM) test. The results showed a significant interaction between groups and moments in homocysteine (F = 4.20, p = 0.02) and IGF-1 (F = 6.97, p <0.01). There were no significant interaction between groups and moments in other biochemical variables (p> 0.05), neither as regards behavioral and cognitive evaluations (p> 0.05). These results suggest that two months of exercise seem to be enough for regulate h omocysteine levels and increased serum levels of IGF-1 in people with PD
Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor impairment due to degeneration of dopaminergic neurons in the nigrostriatal pathway. The most widely used form of treatment is the administration of levodopa (L-Dopa). However, the continued use of this substance in the long term can lead to biochemical, cognitive and behavioral changes. One possible way to alleviate these problems would be physical exercise. Thus, the obje ctive of this study was to analyze the effects of physical exercise on the biochemical, cognitive and behavioral aspects of people with PD. The study included 39 individuals, out of which 11 in a control group (CG) were neurologically healthy and did not practiced physical exercise; 13 in the other control group with DP (CGP) and were not involved in the exercise program; and 15 in the trained group with PD (TGP) who participated in a multimodal exercise program during two months, three times a week, one hour per session. All subjects were evaluated pre-and post-intervention regarding the levels of physical activity, progesterone, estradiol, homocysteine, lactic dehydrogenase, insulin-like growth factor (IGF-1) and glutathione peroxidase. We also evaluated cognitive functions (memory, attention and executive function s). The behavioral variables were anxiety, depressive symptoms and stress. After we collected the data, we compare the results between groups by General Linear Model (GLM) test. The results showed a significant interaction between groups and moments in homocysteine (F = 4.20, p = 0.02) and IGF-1 (F = 6.97, p <0.01). There were no significant interaction between groups and moments in other biochemical variables (p> 0.05), neither as regards behavioral and cognitive evaluations (p> 0.05). These results suggest that two months of exercise seem to be enough for regulate h omocysteine levels and increased serum levels of IGF-1 in people with PD
Descrição
Citação
TANAKA, Kátia. Efeito do exercício físico na doença de Parkinson: Aspectos bioquímicos, cognitivos e comportamentais. 2013. 90 f. Tese (Doutorado em Psicobiologia) – Escola Paulista de Medicina, Universidade Federal de São Paulo. São Paulo, 2013.