Correlation between serum E-selectin levels and panoramic nailfold capillaroscopy in systemic sclerosis

Show simple item record Valim, Valeria [UNIFESP] Assis, L.s.s. [UNIFESP] Simões, Marcia F. J.[UNIFESP] Trevisani, Virgínia Fernandes Moça [UNIFESP] Pucinelli, Mário Luis Cardoso [UNIFESP] Andrade, Luiz Eduardo Coelho [UNIFESP] 2015-06-14T13:31:15Z 2015-06-14T13:31:15Z 2004-09-01
dc.identifier.citation Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 37, n. 9, p. 1423-1427, 2004.
dc.identifier.issn 0100-879X
dc.description.abstract E-selectin is expressed by the activated endothelium and its plasma levels are increased in patients with systemic sclerosis. Eighteen patients fulfilling the American Rheumatism Association criteria for systemic sclerosis, 15 females and 3 males, 42-70 years old, 9 with diffuse and 9 with limited forms, were sequentially recruited for this study. Serum E-selectin levels were determined by commercially available ELISA and their association with nailfold capillaroscopic abnormalities was investigated. Nailfold capillaries were analyzed by 16X magnification wide-field capillaroscopy. Two parameters on capillaroscopy were used to correlate to serum E-selectin: deletion and ectasia. Data were analyzed statistically by the Student t-test and Spearman correlation. Two-tailed P values below 0.05 were considered significant. E-selectin range was 38 to 200 ng/ml (80 ± 39.94). There was a correlation between serum E-selectin levels and the deletion capillaroscopic score (r = 0.50, P < 0.035). This correlation was even stronger within the first 48 months of diagnosis (r = 0.63, P < 0.048). On the other hand, no association was observed between selectin and ectasia. Patients with diffuse disease presented higher serum E-selectin levels than patients with limited disease, although the difference was not statistically significant (96.44 ± 48.04 vs 63.56 ± 21.77 ng/dl; P = 0.08). The present study is the first showing a correlation between soluble serum E-selectin levels and alterations in capillaroscopy. The stronger correlation of deletion score in capillaroscopy in early disease suggests that serum E-selectin levels might be a useful biochemical marker of disease activity in systemic sclerosis. en
dc.format.extent 1423-1427
dc.language.iso eng
dc.publisher Associação Brasileira de Divulgação Científica
dc.relation.ispartof Brazilian Journal of Medical and Biological Research
dc.rights Acesso aberto
dc.subject Systemic sclerosis en
dc.subject Nailfold capillaroscopy en
dc.subject E-selectin en
dc.subject Adhesion molecules en
dc.title Correlation between serum E-selectin levels and panoramic nailfold capillaroscopy in systemic sclerosis en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Divisão de Reumatologia
dc.description.affiliationUnifesp UNIFESP, EPM, Divisão de Reumatologia
dc.identifier.file S0100-879X2004000900018.pdf
dc.identifier.scielo S0100-879X2004000900018
dc.identifier.doi 10.1590/S0100-879X2004000900018
dc.description.source SciELO
dc.identifier.wos WOS:000223707100018


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