Avaliação da eficácia do tratamento do Helicobacter pylori com amoxicilina, claritromicina e lanzoprazol em doentes gastrectomizados por adenocarcinoma gástrico
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Data
2006
Autores
Bertoli Neto, Jose Luiz [UNIFESP]
Orientadores
Lourenço, Laércio Gomes [UNIFESP]
Tipo
Dissertação de mestrado
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Objetivo: Determinar a eficácia da erradicação do Helicobacter pylori em doentes gastrectomizados por adenocarcinoma gástrico em comparação com doentes não gastrectomizados, com o mesmo esquema tríplice. Métodos: Vinte doentes gastrectomizados por adenocarcinoma gástrico com reconstrução em Y de Roux,
infectados por Helicobacter pylori foram comparados com um grupo controle de quarenta doentes não gastrectomizados também infectados. A presença do Helicobacter pylori foi determinada pelo teste ultra-rápido da urease e histologia em material colhido por endoscopia. Ambos os grupos receberam o mesmo
tratamento tríplice. Resultados: A taxa de erradicação do Helicobacter pylori no grupo de estudo foi de 90% e no grupo controle foi de 85%. O sexo, a idade e o tempo de pós-operatório não influenciaram na taxa de erradicação. Conclusões: Não houve diferença estatística na eficácia da erradicação entre os dois grupos,
portanto, o tratamento tríplice é eficaz na erradicação do Helicobacter pylori em doentes gastrectomizados à Y de Roux.
Background. The cause of cancer in the gastric stump is multifactorial and the Helicobacter pylori (HP) is one of these factors. It’s eradication has been recommended, however there are few studies about the eradication of the HP in gastrectomized patients. Methods. Twenty gastrectomized patients for gastric adenocarcinoma and reconstruction in Roux-Y (study group), infected by HP were compared with forty patients (control group) not gastrectomized also infected by the HP. The presence of the HP was determined by the ultra-quick urease test and an histological sample obtained by endoscopy. Both the groups received the same triple therapy regimen. Results. The rate of eradication of the HP in the group of study was of 90% and in the control group was of 85%. Sex, age or post-operative time did not influence in the rate of eradication. Conclusions. There were no differences in the efficacy of the eradication between the two groups, therefore, the triple therapy regimen is efficient in the eradication of the HP in gastrectomized patients with Roux-en-Y diversion technic.
Background. The cause of cancer in the gastric stump is multifactorial and the Helicobacter pylori (HP) is one of these factors. It’s eradication has been recommended, however there are few studies about the eradication of the HP in gastrectomized patients. Methods. Twenty gastrectomized patients for gastric adenocarcinoma and reconstruction in Roux-Y (study group), infected by HP were compared with forty patients (control group) not gastrectomized also infected by the HP. The presence of the HP was determined by the ultra-quick urease test and an histological sample obtained by endoscopy. Both the groups received the same triple therapy regimen. Results. The rate of eradication of the HP in the group of study was of 90% and in the control group was of 85%. Sex, age or post-operative time did not influence in the rate of eradication. Conclusions. There were no differences in the efficacy of the eradication between the two groups, therefore, the triple therapy regimen is efficient in the eradication of the HP in gastrectomized patients with Roux-en-Y diversion technic.
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Citação
BERTOLI NETO, Jose Luiz. Avaliação da eficácia do tratamento do Helicobacter pylori com amoxicilina, claritromicina e lanzoprazol em doentes gastrectomizados por adenocarcinoma gástrico. 2006. 78 f.