Prevalence of codon 72 P53 polymorphism in Brazilian women with cervix cancer
Brenna, Sylvia Michelina Fernandes
Silva, Ismael Dale Cotrim Guerreiro da [UNIFESP]
Zeferino, Luiz Carlos
Pereira, Julia Santucci [UNIFESP]
Martinez, Edson Zachaione
Syrjänen, Kari Juhani
Is part ofGenetics and Molecular Biology
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The p53 codon 72 polymorphism seems to be associated with HPV-carcinogenesis, although controversial data have been reported. A series of Brazilian women with cervix carcinomas were analyzed. Ninety-nine (67%) of 148 women were found to be homozygous (arg/arg) for the arginine polymorphism, and 49 (33%) were heterozygous (arg/pro). This polymorphism may be an important determinant of the risk for cervix cancer, but does not seem to be sufficient for carcinogenesis.
CitationGenetics and Molecular Biology. Sociedade Brasileira de Genética, v. 27, n. 4, p. 496-499, 2004.
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