Prevalence of codon 72 P53 polymorphism in Brazilian women with cervix cancer

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Data
2004-01-01
Autores
Brenna, Sylvia Michelina Fernandes
Silva, Ismael Dale Cotrim Guerreiro da [UNIFESP]
Zeferino, Luiz Carlos
Pereira, Julia Santucci [UNIFESP]
Martinez, Edson Zachaione
Syrjänen, Kari Juhani
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The p53 codon 72 polymorphism seems to be associated with HPV-carcinogenesis, although controversial data have been reported. A series of Brazilian women with cervix carcinomas were analyzed. Ninety-nine (67%) of 148 women were found to be homozygous (arg/arg) for the arginine polymorphism, and 49 (33%) were heterozygous (arg/pro). This polymorphism may be an important determinant of the risk for cervix cancer, but does not seem to be sufficient for carcinogenesis.
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Genetics and Molecular Biology. Sociedade Brasileira de Genética, v. 27, n. 4, p. 496-499, 2004.
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