Estudo eletrofisiologico da epileptogenese em animais submetidos a multiplos status epilepticus duranmte o desenvolvimento

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dc.contributor.author Marques, Ricardo Henrique [UNIFESP]
dc.date.accessioned 2015-12-06T23:01:16Z
dc.date.available 2015-12-06T23:01:16Z
dc.date.issued 2000
dc.identifier.citation São Paulo: [s.n.], 2000. 78 p. ilustabgraf.
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/17093
dc.description.abstract Previous experimental data have shown that neonatal seizures produces several abnormalities which persist in the aduit life. Pilocarpine-induction of consecutive status epilepticus in P7-9 rat pups of severe behavioral and eiectrographic disturbances (hippocampal and neocorticai epiieptiform discharges) in adulthood. Hippocampal slice experiments were undertaken in adult rats to explore some eietrophysiological mechanisms associated with chronic epileptogenesis in such animals. Standard extracellular recordings from CA1 area show an epileptiform responses in animals subjected to neonatal seizures These evoked responses were characterized by multiple population spikes in normal saline (3.5 mM K+). Higher potassium concentration (7.5 mM) promote increased local hyperexcitability mainly subthreshold rebount bursts and spontaneous discharges. The present data demonstrate a chronic hippocampal hyperexcitability as a consequence of multipie seizures in the neonatal period of life pt
dc.format.extent 78 p.
dc.language.iso por
dc.publisher Universidade Federal de São Paulo (UNIFESP)
dc.rights Acesso restrito
dc.subject Epilepsia pt
dc.subject Pilocarpina pt
dc.subject Hipocampo pt
dc.subject Potássio pt
dc.subject Ácido gama-Aminobutírico pt
dc.title Estudo eletrofisiologico da epileptogenese em animais submetidos a multiplos status epilepticus duranmte o desenvolvimento pt
dc.title.alternative Study eletrophysiological of the epileptogenese in animals submitted to multiple status epilepticus during the development en
dc.type Dissertação de mestrado
dc.identifier.file epm-016874.pdf
dc.description.source BV UNIFESP: Teses e dissertações
unifesp.campus Universidade Federal de São Paulo, Escola Paulista de Medicina pt



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