Hernia incisional: modelo experimental em coelhos
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Data
1997
Autores
Carvalho, Zuleica Monteiro de [UNIFESP]
Orientadores
Fagundes, Djalma José [UNIFESP]
Tipo
Dissertação de mestrado
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Resumo
As operacoes realizadas na parede antero-lateral do abdome sao passiveis de uma incidencia consideravel de hernias incisionais, que acarretam graus variaveis de incapacitacao estetica e funcional. Poucos autores descrevem novas tecnicas operatorias para o tratamento da hernia incisional, em animais previamente herniados. Na literatura pesquisada, nao foi encontrado um modelo experimental de hernia incisional em coelhos, surgiu a motivacao do presente trabalho. O objetivo deste estudo foi desenvolver um modelo de hernia ventral experimental a partir de uma tecnica operatoria simples, resultando em hernias de dimensoes e caracteristicas anatomicas cuja descricao possibilite seu estudo e tratamento. O experimento consistiu em operar 37 coelhos. Ao termino da observacao pos-operatoria de 30,45 e 60 dias, cada animal foi reoperado. Foi constatado que todos os animais desenvolveram hernia ventral. Foram realizadas a inspecao da cavum peritonei confeccao de moldes, medicao linear e medicao volumetrica da hernia incisional. Foram realizadas tambem, medicao da forca de ruptura de um segmento da hernia sem a cutis e exame histologico em microscopia optica pela tecnica da hematoxilina-eosina com documentacao fotografica. Para analise dos resultados da variacao de peso do animal; das aderencias; das dimensoes; da forca de ruptura e ocorrencia de obitos, foram aplicados testes estatistico. Foi observado que o revestimento interno da hernia foi pelo tecido cicatricial rico em fibroblastocytus e fibras collagenas formando uma superficie brilhante, continua, sem peritoneum parietale, com poucas e frouxas aderencias. O conjunto das observacoes revelou que o modelo apresenta condicoes tecnicas satisfatorias para o estudo e posterior tratamento de algumas hernias ventrais
Surgical operations often cause abdominal hernia, with functional and aesthetic consequences. A new surgical technique should first be tested in animals, and the first step for such study should be a description of the characteristics of the hernia in the operated animals. As no experimental model of incisional hernia in rabbits has been described to our knowledge, we undertook to remedy to this. This work aims to develop such an experimental model from a simple surgical technique. The description of the anatomic characteristics and dimensions of a model should allow its study and, subsequently, its treatment. The experiment consisted in operating on rabbits and doing a follow up for 30, 45 or 60 days, after which each animal was reoperated on. All of the animals developped a hernia after the first surgery. The second surgery allowed measurements of size, volume, and bursting strength of the scarred tissue, subsequent to the observation of the cavum peritonei and the confection of the hernia casting moulds. Histological examination in optical microscopy, photographic documenting and statistical study were also done along the whole process. The shape, similar to human incisional hernia, the lustrous and even aspect of the surface, the small amount of adherences, the resistance of scarred tissue, and the low mortality rate, all present this model as technically satisfactory for treatment of ventral hernia.
Surgical operations often cause abdominal hernia, with functional and aesthetic consequences. A new surgical technique should first be tested in animals, and the first step for such study should be a description of the characteristics of the hernia in the operated animals. As no experimental model of incisional hernia in rabbits has been described to our knowledge, we undertook to remedy to this. This work aims to develop such an experimental model from a simple surgical technique. The description of the anatomic characteristics and dimensions of a model should allow its study and, subsequently, its treatment. The experiment consisted in operating on rabbits and doing a follow up for 30, 45 or 60 days, after which each animal was reoperated on. All of the animals developped a hernia after the first surgery. The second surgery allowed measurements of size, volume, and bursting strength of the scarred tissue, subsequent to the observation of the cavum peritonei and the confection of the hernia casting moulds. Histological examination in optical microscopy, photographic documenting and statistical study were also done along the whole process. The shape, similar to human incisional hernia, the lustrous and even aspect of the surface, the small amount of adherences, the resistance of scarred tissue, and the low mortality rate, all present this model as technically satisfactory for treatment of ventral hernia.
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Citação
CARVALHO, Zuleica Monteiro de. Hernia incisional: modelo experimental em coelhos. Dissertação (Mestrado em Ciências) - Escola Paulista de Medicina, Universidade Federal de São Paulo (UNIFESP), São Paulo, 1997.