Leucemia Mielóide Aguda t(8;21) após tratamento de hipertiroidismo com iodo radioativo: Leucemia secundária?

Nenhuma Miniatura disponível
Data
2002-04-01
Autores
Bahia, Daniella Marcia Maranhão [UNIFESP]
Chauffaille, Maria de Lourdes Lopes Ferrari [UNIFESP]
Romeo, Maura S. [UNIFESP]
Dias-da-Silva, Magnus Régios [UNIFESP]
Kerbauy, José [UNIFESP]
Orientadores
Tipo
Artigo
Título da Revista
ISSN da Revista
Título de Volume
Resumo
Acute leukemia following treatment with Iodine131 is a rare event. The possible carcinogenic effect of Iodine131 is still not clear and a large series of cases did not show an increased incidence of cancer. A case of AML t(8;21), three years after Iodine131 treatment for hyperthyroidism, is reported. Secondary AML with t(8;21) is described following exposure to drugs that target topoisomerase II and radiotherapy. The controversial potential of Iodine131 as a leukemogenic agent and the fact that t(8;21) is also found in de-novo AML, emphasize the problem in establishing a relationship between these events although this potential can not be ruled out.
Descrição
Citação
Revista Brasileira de Hematologia e Hemoterapia. Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular, v. 24, n. 2, p. 137-138, 2002.
Palavras-chave