Acute buspirone abolishes the expression of behavioral dopaminergic supersensitivity in mice

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dc.contributor.author Queiroz, Claudio Marcos Teixeira de [UNIFESP]
dc.contributor.author Alcântara, F.b. [UNIFESP]
dc.contributor.author Yagüe, A.m.l. [UNIFESP]
dc.contributor.author Bibancos, Theo [UNIFESP]
dc.contributor.author Frussa-Filho, Roberto [UNIFESP]
dc.date.accessioned 2015-06-14T13:29:36Z
dc.date.available 2015-06-14T13:29:36Z
dc.date.issued 2002-02-01
dc.identifier http://dx.doi.org/10.1590/S0100-879X2002000200013
dc.identifier.citation Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 35, n. 2, p. 237-242, 2002.
dc.identifier.issn 0100-879X
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/1350
dc.description.abstract Previous studies have shown that rats withdrawn from long-term treatment with dopamine receptor blockers exhibit dopaminergic supersensitivity, which can be behaviorally evaluated by enhanced general activity observed in an open-field. Recently, it has been reported that co-treatment with the non-benzodiazepine anxiolytic buspirone attenuates the development of haloperidol-induced dopaminergic supersensitivity measured by open-field behavior of rats. The aims of the present study were: 1) to determine, as previously reported for rats, if mice withdrawn from long-term neuroleptic treatment would also develop dopaminergic supersensitivity using open-field behavior as an experimental paradigm, and 2) to examine if acute buspirone administration would attenuate the expression of this behavioral dopaminergic supersensitivity. Withdrawal from long-term haloperidol treatment (2.5 mg/kg, once daily, for 20 days) induced a significant (30%) increase in ambulation frequency (i.e., number of squares crossed in 5-min observation sessions) but did not modify rearing frequency or immobility duration in 3-month-old EPM-M1 male mice observed in the open-field apparatus. Acute intraperitoneal injection of buspirone (3.0 and 10 but not 1.0 mg/kg, 12-13 animals per group) 30 min before open-field exposure abolished the increase in locomotion frequency induced by haloperidol withdrawal. These data suggest that the open-field behavior of mice can be used to detect dopaminergic supersensitivity, whose expression is abolished by acute buspirone administration. en
dc.format.extent 237-242
dc.language.iso eng
dc.publisher Associação Brasileira de Divulgação Científica
dc.relation.ispartof Brazilian Journal of Medical and Biological Research
dc.rights Acesso aberto
dc.subject Buspirone en
dc.subject Haloperidol en
dc.subject Dopaminergic supersensitivity en
dc.subject Tardive dyskinesia en
dc.subject Behavior en
dc.subject Mice en
dc.title Acute buspirone abolishes the expression of behavioral dopaminergic supersensitivity in mice en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Departamento de Farmacologia
dc.description.affiliationUnifesp UNIFESP, EPM, Depto. de Farmacologia
dc.identifier.file S0100-879X2002000200013.pdf
dc.identifier.scielo S0100-879X2002000200013
dc.identifier.doi 10.1590/S0100-879X2002000200013
dc.description.source SciELO
dc.identifier.wos WOS:000174281400013



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