Effects of Sibutramine on the Treatment of Obesity in Patients with Arterial Hypertension

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dc.contributor.author Faria, Alessandra Nunes [UNIFESP]
dc.contributor.author Ribeiro Filho, Fernando Flexa [UNIFESP]
dc.contributor.author Lerário, Daniel Diniz G. [UNIFESP]
dc.contributor.author Kohlmann, Narcia Elisa Bellucci [UNIFESP]
dc.contributor.author Ferreira, Sandra Roberta Gouvea [UNIFESP]
dc.contributor.author Zanella, Maria Teresa [UNIFESP]
dc.date.accessioned 2015-06-14T13:29:35Z
dc.date.available 2015-06-14T13:29:35Z
dc.date.issued 2002-02-01
dc.identifier http://dx.doi.org/10.1590/S0066-782X2002000200006
dc.identifier.citation Arquivos Brasileiros de Cardiologia. Sociedade Brasileira de Cardiologia - SBC, v. 78, n. 2, p. 176-180, 2002.
dc.identifier.issn 0066-782X
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/1342
dc.description.abstract OBJECTIVE: To assess the effects of weight reduction with 10mg of sibutramine or placebo on blood pressure during 24 hours (ambulatory blood pressure monitoring), on left ventricular mass, and on antihypertensive therapy in 86 obese and hypertensive patients for 6 months. METHODS: The patients underwent echocardiography, ambulatory blood pressure monitoring, and measurement of the levels of hepatic enzymes prior to and after treatment with sibutramine or placebo. RESULTS: The group using sibutramine had a greater weight loss than that using placebo (6.7% versus 2.5%; p<0.001), an increase in heart rate (78.3±7.3 to 82±7.9 bpm; p=0.02), and a reduction in the left ventricular mass/height index (105±29.3 versus 96.6±28.58 g/m; p=0.002). Both groups showed similar increases in the levels of alkaline phosphatase and comparable adjustments in antihypertensive therapy; blood pressure, however, did not change. CONCLUSION: The use of sibutramine caused weight loss and a reduction in left ventricular mass in obese and hypertensive patients with no interference with blood pressure or with antihypertensive therapy. en
dc.format.extent 176-180
dc.language.iso eng
dc.publisher Sociedade Brasileira de Cardiologia - SBC
dc.relation.ispartof Arquivos Brasileiros de Cardiologia
dc.rights Acesso aberto
dc.subject sibutramine en
dc.subject obesity en
dc.subject arterial hypertension en
dc.title Effects of Sibutramine on the Treatment of Obesity in Patients with Arterial Hypertension en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo (UNIFESP) Hospital do Rim e Hipertensão
dc.description.affiliationUnifesp UNIFESP, Hospital do Rim e Hipertensão
dc.identifier.file S0066-782X2002000200006.pdf
dc.identifier.scielo S0066-782X2002000200006
dc.identifier.doi 10.1590/S0066-782X2002000200006
dc.description.source SciELO


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