Evaluation of the central activity of the ethanolic extract of Acosmium subelegans (Mohlenbr) in mice

Evaluation of the central activity of the ethanolic extract of Acosmium subelegans (Mohlenbr) in mice

Author Vieira, Ricardo A. Google Scholar
Lapa, Antonio José Autor UNIFESP Google Scholar
Lima, Thereza Cristina Monteiro de Google Scholar
Institution Universidade Federal de Santa Catarina CCB Department of Pharmacology
Universidade Federal de São Paulo (UNIFESP)
Abstract The ethanolic extract (EE) of Acosmium subelegans (Mohlenbr) Yakovl (perobinha-do-campo) was tested to behavioral paradigms in mice to investigate its putative central depressant effect. Oral pretreatment with the EE significantly reduced in a dose-dependent way the locomotor activity and increased by 30-55% the barbiturate sleep duration relatively to control values. At the highest dose (1,0 g.kg-1) it decreased the extension time/flexion time ratio of the maximal electroshockinduced convulsions, enhanced the latency to the pentylenetetrazol-induced convulsions and diminished by 26% the number of seizures, indicating an anticonvulsant action. No changes were observed in the motor coordination, the core temperature, climbing behavior, catalepsy and the plus-maze performance. The preliminary results indicate that the EE of A. subelegans induce a CNS depressant effect, more specifically an anticonvulsant effect that deserve a thorough investigation.
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Date 2002-01-01
Published in Revista Brasileira de Farmacognosia. Sociedade Brasileira de Farmacognosia, v. 12, p. 50-51, 2002.
ISSN 0102-695X (Sherpa/Romeo)
Publisher Sociedade Brasileira de Farmacognosia
Extent 50-51
Origin http://dx.doi.org/10.1590/S0102-695X2002000300024
Access rights Open access Open Access
Type Article
SciELO ID S0102-695X2002000300024 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/1338

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