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dc.contributor.authorNader, Helena Bonciani [UNIFESP]
dc.contributor.authorPinhal, Maria Aparecida da Silva [UNIFESP]
dc.contributor.authorBaú, Elaine Cristina [UNIFESP]
dc.contributor.authorCastro, Ricardo Augusto Braga de [UNIFESP]
dc.contributor.authorMedeiros, Guilherme Fulgencio [UNIFESP]
dc.contributor.authorChavante, Suely Ferreira [UNIFESP]
dc.contributor.authorLeite, Edda Lisboa [UNIFESP]
dc.contributor.authorTrindade, Edvaldo da Silva [UNIFESP]
dc.contributor.authorShinjo, Samuel Katsuyuki [UNIFESP]
dc.contributor.authorRocha, Hugo Alexandre Oliveira [UNIFESP]
dc.contributor.authorTersariol, Ivarne Luis dos Santos [UNIFESP]
dc.contributor.authorMendes, Aline [UNIFESP]
dc.contributor.authorDietrich, Carl Peter [UNIFESP]
dc.date.accessioned2015-06-14T13:29:25Z
dc.date.available2015-06-14T13:29:25Z
dc.date.issued2001-06-01
dc.identifierhttp://dx.doi.org/10.1590/S0100-879X2001000600002
dc.identifier.citationBrazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 34, n. 6, p. 699-709, 2001.
dc.identifier.issn0100-879X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/1184
dc.description.abstractThe anticlotting and antithrombotic activities of heparin, heparan sulfate, low molecular weight heparins, heparin and heparin-like compounds from various sources used in clinical practice or under development are briefly reviewed. Heparin isolated from shrimp mimics the pharmacological activities of low molecular weight heparins. A heparan sulfate from Artemia franciscana and a dermatan sulfate from tuna fish show a potent heparin cofactor II activity. A heparan sulfate derived from bovine pancreas has a potent antithrombotic activity in an arterial and venous thrombosis model with a negligible activity upon the serine proteases of the coagulation cascade. It is suggested that the antithrombotic activity of heparin and other antithrombotic agents is due at least in part to their action on endothelial cells stimulating the synthesis of an antithrombotic heparan sulfate.en
dc.format.extent699-709
dc.language.isoeng
dc.publisherAssociação Brasileira de Divulgação Científica
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.rightsAcesso aberto
dc.subjectheparin, anticlotting activityen
dc.subjectheparan sulfate, antithrombotic activityen
dc.subjectlow molecular weight heparins, preparation and antithrombotic activityen
dc.subjectantithrombotic agents, development for clinical useen
dc.subjectcrustacean heparin-like compounds, antithrombotic activityen
dc.subjectantithrombotic agentsen
dc.subjectvascular endothelial cellsen
dc.titleDevelopment of new heparin-like compounds and other antithrombotic drugs and their interaction with vascular endothelial cellsen
dc.typeArtigo
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Federal do Rio Grande do Norte Departamento de Oceanografia
dc.contributor.institutionUniversidade Federal do Rio Grande do Norte Departamento de Bioquímica
dc.contributor.institutionUniversidade de Mogi das Cruzes Centro de Investigação Bioquímica
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Departamento de Bioquímica
dc.description.affiliationUniversidade Federal do Rio Grande do Norte Departamento de Oceanografia
dc.description.affiliationUniversidade Federal do Rio Grande do Norte Departamento de Bioquímica
dc.description.affiliationUniversidade de Mogi das Cruzes Centro de Investigação Bioquímica
dc.description.affiliationUnifespUNIFESP, EPM, Depto. de Bioquímica
dc.identifier.fileS0100-879X2001000600002.pdf
dc.identifier.scieloS0100-879X2001000600002
dc.identifier.doi10.1590/S0100-879X2001000600002
dc.description.sourceSciELO
dc.identifier.wosWOS:000169443400002


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