Now showing items 1-6 of 6

    • Age-related mitochondrial DNA point mutations in patients with mitochondrial myopathy 

      Costa, Carina K. da [UNIFESP]; Kiyomoto, Beatriz H. [UNIFESP]; Schmidt, Beny [UNIFESP]; Oliveira, Acary S. B. [UNIFESP]; Gabbai, Alberto Alain [UNIFESP]; Tengan, Celia H. [UNIFESP] (Elsevier B.V., 2007-12-15)
      Mutations in the control region (D-loop) of mitochondrial DNA (mtDNA) have been described in normal old individuals and it is suggested that they originated from oxidative damage. Respiratory chain defects may lead to ...
    • Effects of short-term zidovudine exposure on mitochondrial DNA content and succinate dehydrogenase activity of rat skeletal muscle cells 

      Kiyomoto, Beatriz H. [UNIFESP]; Tengan, Celia H. [UNIFESP]; Godinho, Rosely O. [UNIFESP] (Elsevier B.V., 2008-05-15)
      Long-term use of zidovudine (AZT) may cause mitochondrial abnormalities in various tissues, including a toxic myopathy in AIDS patients associated with mitochondrial DNA (mtDNA) depletion. in the present study, we examine ...
    • Frequency of duplications in the D-loop in patients with mitochondrial DNA deletions 

      Tengan, Célia Harumi [UNIFESP].; Ferreiro-Barros, Claudia Cristina [UNIFESP]; Cardeal, Marina [UNIFESP]; Fireman, Moacir Antonio Tenorio; Oliveira, Acary Souza Bulle [UNIFESP]; Kiyomoto, Beatriz Hitomi [UNIFESP]; Gabbai, Alberto Alain [UNIFESP] (Elsevier B.V., 2002-10-09)
      Small duplications (miniduplications) of the D-loop of human mitochondrial DNA (mtDNA) have been described in patients with mtDNA deletions, mtDNA point mutations and in normal aged tissues. the origin of these miniduplications ...
    • Investigation of mitochondrial involvement in the experimental model of epilepsy induced by pilocarpine 

      Nasseh, I. E.; Amado, D.; Cavalheiro, E. A.; Naffah-Mazzacoratti, M. D.; Tengan, C. H. (Elsevier B.V., 2006-03-01)
      Mitochondrial abnormalities have been associated with several aspects of epileptogenesis, such as energy generation, control of cell death, neurotransmitter synthesis, and free radical (FR) production. Increased production ...
    • Mitochondrial DNA defects in Brazilian patients with chronic progressive external ophthalmoplegia 

      Kiyomoto, B. H.; Tengan, C. H.; Moraes, C. T.; Oliveira, ASB; Gabbai, Alberto Alain [UNIFESP] (Elsevier B.V., 1997-11-25)
      We report herein on eleven Brazilian patients with mitochondrial DNA (mtDNA) deletions, found among thirteen patients with chronic progressive external ophthalmoplegia (CPEO) and ragged-red fibers (RRF). the molecular data ...
    • Nitric Oxide Synthesis Is Increased in Cybrid Cells with m.3243A > G Mutation 

      Gamba, Juliana [UNIFESP]; Gamba, Luana Tesser [UNIFESP]; Rodrigues, Gabriela S. [UNIFESP]; Kiyomoto, Beatriz Hitomi [UNIFESP]; Moraes, Carlos T.; Tengan, Celia Harumi [UNIFESP] (Mdpi Ag, 2013-01-01)
      Nitric oxide (NO) is a free radical and a signaling molecule in several pathways, produced by nitric oxide synthase (NOS) from the conversion of L-arginine to citrulline. Supplementation of L-arginine has been used to treat ...