Now showing items 1-10 of 41

    • Age-related mitochondrial DNA point mutations in patients with mitochondrial myopathy 

      Costa, Carina K. da [UNIFESP]; Kiyomoto, Beatriz H. [UNIFESP]; Schmidt, Beny [UNIFESP]; Oliveira, Acary S. B. [UNIFESP]; Gabbai, Alberto Alain [UNIFESP]; Tengan, Celia H. [UNIFESP] (Elsevier B.V., 2007-12-15)
      Mutations in the control region (D-loop) of mitochondrial DNA (mtDNA) have been described in normal old individuals and it is suggested that they originated from oxidative damage. Respiratory chain defects may lead to ...
    • Analysis of the functional aspects and seminal plasma proteomic profile of sperm from smokers 

      Antoniassi, Mariana Pereira [UNIFESP]; Intasqui, Paula [UNIFESP]; Camargo, Mariana [UNIFESP]; Zylbersztejn, Daniel Suslik [UNIFESP]; Carvalho, Valdemir Melechco; Cardozo, Karina H. M.; Bertolla, Ricardo Pimenta [UNIFESP] (Wiley, 2016)
      Objective To evaluate the effect of smoking on sperm functional quality and seminal plasma proteomic profile. Patients and Methods Sperm functional tests were performed in 20 non-smoking men with normal semen quality, ...
    • Análise proteômica quantitativa de plasma seminal e sua associação com aspectos funcionais dos espermatozoides e com o nível de peroxidação lipídica no plasma seminal 

      Intasqui Lopes, Paula [UNIFESP] (Universidade Federal de São Paulo (UNIFESP), 2014)
      funcionais nos espermatozoides e o nivel seminal de peroxidacao lipidica. Metodo: Um estudo transversal foi realizado incluindo 156 pacientes normozoospermicos. Apos a coleta do semen por masturbacao, uma aliquota foi ...
    • Apoptotic effect of ethanol is potentiated by caffeine-induced calcium release in rat astrocytes 

      Hirata, H.; Machado, L. S.; Okuno, C. S.; Brasolin, A.; Lopes, G. S.; Smaili, Soraya Soubhi [UNIFESP] (Elsevier B.V., 2006-01-30)
      In this study, we investigated agents that increased intracellular calcium levels and their correlation with apoptotic cell death induction. We used rat astrocytes to investigate the increase in cytosolic Ca2+, (Ca-c(2+)) ...
    • Association between the seminal plasma proteome and sperm functional traits 

      Intasqui, Paula [UNIFESP]; Camargo, Mariana [UNIFESP]; Antoniassi, Mariana Pereira [UNIFESP]; Cedenho, Agnaldo Pereira [UNIFESP]; Carvalho, Valdemir Melechco; Morais Cardozo, Karina Helena; Zylbersztejn, Daniel Suslik [UNIFESP]; Bertolla, Ricardo Pimenta [UNIFESP] (Elsevier Science Inc, 2016)
      Objective: To analyze the seminal plasma proteome and biological functions associated with sperm functional alterations. Design: Cross-sectional study. Setting: University andrology and research laboratories. Patient(s): ...
    • Astaxanthin Restrains Nitrative-Oxidative Peroxidation in Mitochondrial-Mimetic Liposomes: A Pre-Apoptosis Model 

      Mano, Camila M.; Guaratini, Thais; Cardozo, Karina H. M.; Colepicolo, Pio; Bechara, Etelvino José Henriques [UNIFESP]; Barros, Marcelo P. (Mdpi, 2018)
      Astaxanthin (ASTA) is a ketocarotenoid found in many marine organisms and that affords many benefits to human health. ASTA is particularly effective against radical-mediated lipid peroxidation, and recent findings hypothesize ...
    • Bax affects intracellular Ca2+ stores and induces Ca2+ wave propagation 

      Carvalho, ACP; Sharpe, J.; Rosenstock, T. R.; Teles, AFV; Youle, R. J.; Smaili, Soraya Soubhi [UNIFESP] (Nature Publishing Group, 2004-12-01)
      In the present study, we evaluated proapoptotic protein Bax on mitochondria and Ca2+ homeostasis in primary cultured astrocytes. We found that recombinant Bax (rBax, 10 and 100 ng/ml) induces a loss in mitochondrial membrane ...
    • Bax translocation to mitochondria subsequent to a rapid loss of mitochondrial membrane potential 

      Smaili, Soraya Soubhi [UNIFESP]; Hsu, Y. T.; Sanders, K. M.; Russel, J. T.; Youle, R. J. (Nature Publishing Group, 2001-09-01)
      Bax, a pro-apoptotic member of the Bcl-2 family, is a cytosolic protein that inserts into mitochondrial membranes upon induction of cell death. Using the green fluorescent protein fused to Bax (GFP-Bax) to quantitate ...
    • Bcl-X-L inhibits Bax-induced alterations in mitochondrial respiration and calcium release 

      Teles, A. V. F. [UNIFESP]; Ureshino, R. P. [UNIFESP]; Dorta, D. J. [UNIFESP]; Lopes, G. S. [UNIFESP]; Hsu, Y. -T.; Smaili, Soraya Soubhi [UNIFESP] (Elsevier B.V., 2008-09-12)
      Apoptosis is a natural cell elimination process involved in a number of physiological and pathological events. This process can be regulated by members of the Bcl-2 family. Bax, a pro-apoptotic member of this family, ...
    • Calcium and cell death signaling in neurodegeneration and aging 

      Smaili, Soraya Soubhi [UNIFESP]; Hirata, Hanako [UNIFESP]; Ureshino, Rodrigo Portes [UNIFESP]; Monteforte, Priscila T. [UNIFESP]; Morales, Ana P. [UNIFESP]; Muler, Mari Luminosa [UNIFESP]; Terashima, Juliana [UNIFESP]; Oseki, Karen Tubono [UNIFESP]; Rosenstock, Tatiana R. [UNIFESP]; Lopes, Guiomar Silva [UNIFESP]; Bincoletto, Claudia [UNIFESP] (Academia Brasileira de Ciências, 2009-09-01)
      Transient increase in cytosolic (Cac2+) and mitochondrial Ca2+ (Ca m2+) are essential elements in the control of many physiological processes. However, sustained increases in Ca c2+ and Ca m2+ may contribute to oxidative ...