Now showing items 1-10 of 71

    • Altered neutrophil homeostasis in kinin B1 receptor-deficient mice 

      Araujo, R. C.; Kettritz, R.; Fichtner, I; Paiva, ACM; Pesquero, J. B.; Bader, M. (Walter de Gruyter & Co, 2001-01-01)
      The kallikrein-kinin system is activated during inflammation and plays a major role in the inflammatory process. One of the main mechanisms of kinin action includes the modulation of neutrophil function employing both ...
    • Biochemical and pharmacological aspects of two bradykinin-potentiating peptides obtained from tryptic hydrolysis of casein 

      Perpetuo, Elen Aquino; Juliano, Luis [UNIFESP]; Lebrun, Ivo (Kluwer Academic/plenum Publ, 2003-11-01)
      Peptides that display bradykinin-potentiating activity have been obtained from a number of distinct sources, such as snake venoms, fibrinogen, and casein. This paper describes the characterization of two new peptides ...
    • Blockade of Bradykinin Receptor B1 but Not Bradykinin Receptor B2 Provides Protection From Cerebral Infarction and Brain Edema 

      Austinat, Madeleine; Braeuninger, Stefan; Pesquero, João Bosco [UNIFESP]; Brede, Marc; Bader, Michael [UNIFESP]; Stoll, Guido; Renne, Thomas; Kleinschnitz, Christoph (Lippincott Williams & Wilkins, 2009-01-01)
      Background and Purpose-Brain edema is detrimental in ischemic stroke and its treatment options are limited. Kinins are proinflammatory peptides that are released during tissue injury. the effects of kinins are mediated by ...
    • Bradykinin induces a calcium-store-dependent calcium influx in mouse mesangial cells 

      Campos, A. H.; Calixto, J. B.; Schor, N. (Karger, 2002-06-01)
      Bradykinin (BK) elicits extracellular-dependent [Ca2+]i elevations in mouse mesangial cells (MMC) that are not blocked by verapamil, nifeclipine, L-nicardipine, NiCl2, or LaCl3. the aim of the present study was to evaluate ...
    • Bradykinin inhibits hepatic gluconeogenesis in obese mice 

      Barros, Carlos Castilho [UNIFESP]; Haro, Anderson [UNIFESP]; Russo, Fernanda Jaqueline [UNIFESP]; Schadock, Ines; Almeida, Sandro Soares [UNIFESP]; Reis, Felipe Castellani [UNIFESP]; Moraes, Milton Rocha [UNIFESP]; Haidar, Andre [UNIFESP]; Hirata, Aparecida Emiko [UNIFESP]; Mori, Marcelo [UNIFESP]; Pereira Bacurau, Reury Frank; Wurtele, Martin [UNIFESP]; Bader, Michael; Pesquero, Joao Bosco [UNIFESP]; Araujo, Ronaldo Carvalho [UNIFESP] (Nature Publishing Group, 2012-10-01)
      The kallikrein-kinin system (KKS) has been previously linked to glucose homeostasis. in isolated muscle or fat cells, acute bradykinin (BK) stimulation was shown to improve insulin action and increase glucose uptake by ...
    • Bradykinin release and inactivation in brain of rats submitted to an experimental model of Alzheimer's disease 

      Iores-Marcal, Ligia M. [UNIFESP]; Viel, Tania A.; Buck, Hudson Sousa; Nunes, Viviane A. [UNIFESP]; Gozzo, Andrezza Justino [UNIFESP]; Cruz-Silva, Ilana [UNIFESP]; Miranda, Antonio [UNIFESP]; Shimamoto, Kazuaki; Ura, Nobuyuki; Araujo, Mariana S. [UNIFESP] (Elsevier B.V., 2006-12-01)
      The kallikrein-kinin system is involved in a variety of physiological and pathological processes. Components of this system, identified in rat and human brains, can be altered in neurodegenerative processes such as Alzheimer's ...
    • Characterization of a kinin inactivating serine endopeptidase H2 (kininase) from human urine using fluorogenic substrates 

      Quinto, BMR; Juliano, L.; Juliano, M.; Carmona, A. K.; Stella, RCR; Casarini, D. E. (Elsevier B.V., 1999-12-01)
      We have previously described a kinin-inactivating endopeptidase (H2), which was purified 19-fold from human urine by DEAE-cellulose chromatography and gel filtration. the enzyme was inhibited 100% by PMSF, TPCK and pOHMB. ...
    • Chondroitin sulfate and kallikrein in saliva: Markers for glossodynia 

      Loeb, L. M. [UNIFESP]; Naffah-Mazzacoratti, M. G. [UNIFESP]; Porcionatto, M. A. [UNIFESP]; Martins, J. R. M. [UNIFESP]; Kouyoumdjian, M. [UNIFESP]; Weckx, L. M. [UNIFESP]; Nader, H. B. [UNIFESP] (Elsevier B.V., 2008-07-01)
      Glossodynia or burning mouth syndrome is a multifunctional disorder. the oral mucosa is apparently normal but patients report burning and dried mouth and painful tongue and lips. the present study reports biochemical and ...
    • Comparative substrate specificity analysis of recombinant human cathepsin V and cathepsin L 

      Puzer, L.; Cotrin, S. S.; Alves, MFM; Egborge, T.; Araujo, M. S.; Juliano, M. A.; Juliano, L.; Bromme, D.; Carmona, A. K. (Elsevier B.V., 2004-10-15)
      Cathepsins V and L have high identity and few structural differences. in this paper, we reported a comparative study of the hydrolytic activities of recombinant human cathepsins V and L using fluorescence resonance energy ...
    • Conformational and biological properties of Bauhinia bauhinioides kallikrein inhibitor fragments with bradykinin-like activities 

      Alves, Flavio Lopes [UNIFESP]; Oliva, Maria Luiza Vilela [UNIFESP]; Miranda, Antonio [UNIFESP] (Wiley-Blackwell, 2015-06-01)
      Proteinase inhibitors extracted form medicinal plants are an interesting source of new drugs. Modifications in the structure of some of this kind of macromolecules could also lead to compounds of interesting biological ...