Now showing items 1-10 of 68

    • Aerobic exercise reduces hippocampal ERK and p38 activation and improves memory of middle-aged rats 

      Cardoso, Fabrizio dos Santos; Franca, Erivelton Fernandes; Serra, Fernando Tadeu; Victorino, Angelica Begatti [UNIFESP]; de Almeida, Alexandre Aparecido [UNIFESP]; Fernandes, Jansen [UNIFESP]; Cabral, Francisco Romero; Venancio, Daniel Paulino; Arida, Ricardo Mario [UNIFESP]; da Silva, Sergio Gomes (Wiley, 2017)
      Aging is often accompanied by cognitive decline, memory impairment, and an increased susceptibility to neurodegenerative disorders. Although the physiological processes of aging are not fully understood, these age-related ...
    • Age-associated mosaicism and polyploidy in Down's syndrome 

      Borsatto, B.; Arruda, M. de; Smith, C.; Garcez, EMDM; Peres, C. A. (Elsevier B.V., 1998-01-12)
      Age-related increases in the frequencies of cells with chromosome 21 loss and of polyploid cells were documented in short-term peripheral blood lymphocyte cultures from 54 patients with Down's syndrome (DS), ages 0 to 48 ...
    • Age-related mitochondrial DNA point mutations in patients with mitochondrial myopathy 

      Costa, Carina K. da [UNIFESP]; Kiyomoto, Beatriz H. [UNIFESP]; Schmidt, Beny [UNIFESP]; Oliveira, Acary S. B. [UNIFESP]; Gabbai, Alberto Alain [UNIFESP]; Tengan, Celia H. [UNIFESP] (Elsevier B.V., 2007-12-15)
      Mutations in the control region (D-loop) of mitochondrial DNA (mtDNA) have been described in normal old individuals and it is suggested that they originated from oxidative damage. Respiratory chain defects may lead to ...
    • Agiong-related changes of intracellular Ca2+ stores and contractile response of intestinal smooth muscle 

      Lopes, G. S.; Ferreira, A. T.; Oshiro, M. E.; Vladmirova, I; Jurkiewicz, N. H.; Jurkiewicz, A.; Smaili, Soraya Soubhi [UNIFESP] (Elsevier B.V., 2006-01-01)
      In this study, we investigated the effect of aging on intracellular Ca2+ stores, as sarcoendoplasmic reticulum (SR) and mitochondria, and the influence of these compartments on contraction of rat colon smooth muscle [Bitar, ...
    • Alcohol and tobacco consumption concordance and its correlates in older couples in Latin America 

      Alves Machado, Mayra Pires [UNIFESP]; Opaleye, Davi Camara [UNIFESP]; Pereira, Tiago Veiga; Padilla, Ivan [UNIFESP]; Noto, Ana Regina [UNIFESP]; Prince, Martin; Ferri, Cleusa Pinheiro [UNIFESP] (Wiley, 2017)
      AimAs little is known about alcohol and tobacco consumption concordance between older spouses in low- and middle-income countries, the present study aimed to estimate this in older couples from five Latin American countries. ...
    • Alterations in Calcium Signaling and a Decrease in Bcl-2 Expression: Possible Correlation With Apoptosis in Aged Striatum 

      Ureshino, R. P. [UNIFESP]; Bertoncini, C. R. [UNIFESP]; Fernandes, M. J. S.; Abdalla, F. M. F.; Porto, C. S. [UNIFESP]; Hsu, Y-T.; Lopes, G. S. [UNIFESP]; Smaili, Soraya Soubhi [UNIFESP] (Wiley-Blackwell, 2010-02-01)
      Aging is a multifaceted process associated with various functional and structural deficits that might be evolved in degenerative diseases. It has been shown that neurodegenerative disorders are associated with alterations ...
    • ANALYSIS of SNAP25 mRNA EXPRESSION and PROMOTER DNA METHYLATION in BRAIN AREAS of ALZHEIMER'S DISEASE PATIENTS 

      Furuya, T. K. [UNIFESP]; Silva, P. N. O. [UNIFESP]; Payao, S. L. M. [UNIFESP]; Bertolucci, P. H. F. [UNIFESP]; Rasmussen, L. T.; De Labio, R. W.; Braga, I. L. S. [UNIFESP]; Chen, E. S. [UNIFESP]; Turecki, G.; Mechawar, N.; Mill, J.; Smith, M. A. C. [UNIFESP] (Elsevier B.V., 2012-09-18)
      Alzheimer's Disease (AD) is the most common cause of dementia in elderly people. the presynaptic terminal is an important site of pathological changes in AD, leading to synaptic loss in specific brain regions, such as in ...
    • Análise quantitativa das fibras mielínicas dos nervos laríngeos em humanos de acordo com a idade 

      Tiago, Romualdo Suzano Louzeiro [UNIFESP]; Pontes, Paulo Augusto de Lima [UNIFESP]; Brasil, Osiris de Oliveira Campones do [UNIFESP] (ABORL-CCF Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial, 2008-02-01)
      INTRODUCTION AND AIM: To carry out a morphometric analysis of myelinic fibers in laryngeal nerves aiming to identify quantitative changes as a result of aging. Study design: Clinical and experimental. MATERIAL AND METHOD: ...
    • Antioxidant defense in rat brain after chronic treatment with anorectic drugs 

      DAlmeida, V; Camarini, R.; Azzalis, L. A.; Mattei, R.; Junqueira, VBC; Carlini, E. A. (Elsevier B.V., 1995-11-15)
      Mazindol (5-hydroxy-5-p-chlorophenyl-2,3-dihydro-5H-isoindole) although not chemically related to the phenylethylamine group, shows a pharmacological profile similar to that of amphetamines. in rats these anorectic drugs ...
    • Aspectos morfométricos do nervo hipoglosso humano em adultos e idosos 

      Tiago, Romualdo Suzano Louzeiro [UNIFESP]; Faria, Flavio Paulo de [UNIFESP]; Pontes, Paulo Augusto de Lima [UNIFESP]; Brasil, Osíris de Oliveira Camponês do [UNIFESP] (ABORL-CCF Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial, 2005-10-01)
      AIM: Perform a morphometric analysis of the myelinic fibers of the right hypoglossal nerve, in two age groups; to verify quantitative changes as a result of the aging process. STUDY DESIGN: anatomic. MATERIAL AND METHOD: ...