Now showing items 1-7 of 7

    • Acquired hemoglobin H disease in a patient with aplastic anemia evolving into acute myeloid leukemia 

      Figueiredo, Maria Stella [UNIFESP]; Vicari, Perla [UNIFESP]; Kimura, Eliza Yuriko Sugano [UNIFESP]; Antunes, Sandra Vallin [UNIFESP]; Yamamoto, Mihoko [UNIFESP] (Associação Paulista de Medicina - APM, 2004-12-01)
      CONTEXT: The prognosis of severe aplastic anemia has improved since the introduction of bone marrow transplantation and treatment with antithymocyte globulin. In contrast to the success of these protocols, studies with ...
    • The ambiguous role of interferon regulatory factor-1 (IRF-1) immunoexpression in myelodysplastic syndrome 

      Pinheiro, Ronald Feitosa [UNIFESP]; Metze, Konradin; Regis Silva, Maria Regina [UNIFESP]; Lopes Ferrari Chauffaille, Maria de Lourdes [UNIFESP] (Elsevier B.V., 2009-10-01)
      Recent investigations postulate a participation of the interferon regulatory factor-1 (IRF-1) in the development of myelodysplasia (MDS) and in the pathogenesis of autoimmune manifestations (AIMs) in patients with this ...
    • Distinct expression profiles of MSI2 and NUMB genes in myelodysplastic syndromes and acute myeloid leukemia patients 

      Pereira, João Kleber Novais; Traina, Fabíola; Machado-Neto, João Agostinho; Duarte, Adriana da Silva Santos; Saad, Sara Teresinha Olalla; Favaro, Patricia [UNIFESP]; Lopes, Matheus Rodrigues (Elsevier B.V., 2012-10-01)
      Recent studies have indicated the Musashi2/NUMB pathway as the key regulator of differentiation in chronic myeloid leukemia; however, a comparison of both gene expressions has not yet been made in myelodysplastic syndrome ...
    • Downregulation of IRS2 in myelodysplastic syndrome: A possible role in impaired hematopoietic cell differentiation 

      Machado-Neto, Joao Agostinho; Favaro, Patricia [UNIFESP]; Lazarini, Mariana; Santos Duarte, Adriana da Silva; Archangelo, Leticia Froehlich; Lorand-Metze, Irene; Costa, Fernando Ferreira; Olalla Saad, Sara Teresinha; Traina, Fabiola (Elsevier B.V., 2012-07-01)
      Insulin receptor substrate 2 (IRS2) is an adaptor protein that associates with the receptor of erythropoietin, insulin-like growth factor 1 and thrombopoietin; however, its role is not known in myelodysplasia. We, herein, ...
    • Hyperfibrotic myelodysplasia: case report with response to steroid therapy 

      Romeo, Maura [UNIFESP]; Chauffaille, Maria de Lourdes Lopes Ferrari [UNIFESP]; Bahia, Daniella Marcia Maranhão [UNIFESP]; Silva, Maria Regina Regis (Sociedade Brasileira de Patologia ClínicaSociedade Brasileira de PatologiaSociedade Brasileira de Citopatologia, 2002-01-01)
      Context: Bone marrow fibrosis is observed in different clonal hematological disorders including myeloproliferative diseases, acute leukemias and myelodysplastic syndromes. In myelodysplastic syndrome a new clinical-pathological ...
    • Pioderma gangrenoso bolhoso e síndrome mielodisplásica 

      Batista, Mariana Dias [UNIFESP]; Fernandes, Ricardo Limongi [UNIFESP]; Rocha, Marco Alexandre Dias Da [UNIFESP]; Ikino, Juliana Kida [UNIFESP]; Pinheiro, Ronald Feitosa [UNIFESP]; Chauffaille, Maria de Lourdes Lopes Ferrari [UNIFESP]; Michalany, Nílceo Schwery [UNIFESP]; Almeida, Fernando Augusto De [UNIFESP] (Sociedade Brasileira de Dermatologia, 2006-10-01)
      Pyoderma gangrenosum can present as a cutaneous manifestation of paraneoplastic syndromes. A case of bullous pyoderma gangrenosum associated with bicytopenia is described. During the complementary investigation, myelogram, ...
    • Stathmin 1 is involved in the highly proliferative phenotype of high-risk myelodysplastic syndromes and acute leukemia cells 

      Machado-Neto, Joao Agostinho; Campos, Paula de Melo; Favaro, Patricia [UNIFESP]; Lazarini, Mariana; Lorand-Metze, Irene; Costa, Fernando Ferreira; Olalla Saad, Sara Teresinha; Traina, Fabiola (Elsevier B.V., 2014-02-01)
      Stathmin 1 is an important cytoplasmic microtubule-destabilizing protein that plays critical roles in proliferation and accurate chromosome segregation through regulation of microtubule dynamics. High levels of Stathmin 1 ...