Now showing items 1-10 of 22

    • Bauhinia forficata lectin (BfL) induces cell death and inhibits integrin-mediated adhesion on MCF7 human breast cancer cells 

      Silva, Mariana C. C. [UNIFESP]; Paula, Claudia A. A. de [UNIFESP]; Ferreira, Joana G. [UNIFESP]; Paredes-Gamero, Edgar Julian [UNIFESP]; Vaz, Angela M. S. F.; Sampaio, Misako U. [UNIFESP]; Correia, Maria Tereza S.; Oliva, Maria Luiza V. [UNIFESP] (Elsevier B.V., 2014-07-01)
      Background: Plant lectins have attracted great interest in cancer studies due to their antitumor activities. These proteins or glycoproteins specifically and reversibly bind to different types of carbohydrates or glycoproteins. ...
    • BFD-22 a new potential inhibitor of BRAF inhibits the metastasis of B16F10 melanoma cells and simultaneously increased the tumor immunogenicity 

      Ferreira, Adilson Kleber; Mesquita Pasqualoto, Kerly Fernanda; Kruyt, Frank A. E.; Palace-Berl, Fanny; Azevedo, Ricardo Alexandre; Turra, Kely Medeiros; Rodrigues, Cecilia Pessoa; Franco Ferreira, Ana Carolina; Clavijo Salomon, Maria Alejandra; de Sa Junior, Paulo Luiz; Farias, Camyla Fernandes [UNIFESP]; Figueiredo, Carlos Rogerio [UNIFESP]; Tavares, Leoberto Costa; Marzagdo Barbuto, Jose Alexandre; Jorge, Salomao Doria (Academic Press Inc Elsevier Science, 2016)
      Benzofuroxan is an interesting ring system, which has shown a wide spectrum of biological responses against tumor cell lines. We investigated, herein, the antitumor effects of benzofuroxan derivatives (BFDs) in vitro and ...
    • Bothropoides insularis venom cytotoxicity in renal tubular epithelia cells 

      Mello, Clarissa P.; Morais, Isabel C. O.; Menezes, Ramon R. P. P. B.; Pereira, Gustavo J. S. [UNIFESP]; Torres, Alba F. C.; Lima, Danya B.; Pereira, Ticiana P.; Toyama, Marcos H.; Monteiro, Helena S. A.; Smaili, Soraya Soubhi [UNIFESP]; Martins, Alice M. C. (Elsevier B.V., 2014-09-15)
      Bothropoides insularis (jararaca-ilhoa) is a native endemic snake limited to the specific region of Queimada Island, on São Paulo coast. Several local and systemic effects have been described due to envenomation caused by ...
    • Canthin-6-one induces cell death, cell cycle arrest and differentiation in human myeloid leukemia cells 

      Vieira Torquato, Heron F. [UNIFESP]; Ribeiro-Filho, Antonio C.; Buri, Marcus V. [UNIFESP]; Araujo Junior, Roberto T. [UNIFESP]; Pimenta, Renata [UNIFESP]; de Oliveira, Jose Salvador R. [UNIFESP]; Filho, Valdir C.; Macho, Antonio; Paredes-Gamero, Edgar J. [UNIFESP]; de Oliveira Martins, Domingos T. (Elsevier Science Bv, 2017)
      Background: Canthin-6-one is a natural product isolated from various plant genera and from fungi with potential antitumor activity. In the present study, we evaluate the antitumor effects of canthin-6-one in human myeloid ...
    • Characterization of dual effects induced by antimicrobial peptides: Regulated cell death or membrane disruption 

      Paredes-Gamero, Edgar Julian [UNIFESP]; Martins, Marta Natividade Crizol [UNIFESP]; Cappabianco, Fabio Augusto Menocci [UNIFESP]; Ide, Jaime Shinsuke [UNIFESP]; Miranda, Antonio [UNIFESP] (Elsevier B.V., 2012-07-01)
      Background: Some reports describe lysis mechanisms by antimicrobial peptides (AMPs), while others describe the activation of regulated cell death. in this study, we compare the cell death-inducing activities of four ...
    • Cimetidine-induced vascular cell apoptosis impairs testicular microvasculature in adult rats 

      Beltrame, Flavia Luciana [UNIFESP]; Yamauti, Caroline T.; Caneguim, Breno Henrique [UNIFESP]; Cerri, Paulo Sergio [UNIFESP]; Miraglia, Sandra Maria [UNIFESP]; Sasso-Cerri, Estela [UNIFESP] (F Hernandez, 2012-10-01)
      Cimetidine, an H-2 receptor antagonist used for treatment of gastric ulcers, exerts antiandrogenic and antiangiogenic effects. In the testes cimetidine impairs spermatogenesis, Sertoli cells and peritubular tissue, inducing ...
    • Consequences of pilocarpine-induced status epilepticus in immunodeficient mice 

      Vignoli, Thiago [UNIFESP]; Nehlig, Astrid; Massironi, Silvia Gomes; Sinigaglia Coimbra, Rita de Cassia [UNIFESP]; Naffah Mazzacoratti, Maria da Graca [UNIFESP]; Silva, Iara Ribeiro [UNIFESP]; Castro Neto, Eduardo Ferreira de [UNIFESP]; Persike, Daniele Suzete [UNIFESP]; Silva Fernandes, Maria Jose da [UNIFESP] (Elsevier B.V., 2012-04-23)
      Systemic injection of pilocarpine in rodents induces status epilepticus (SE) and reproduces the main characteristics of temporal lobe epilepsy (TLE). Different mechanisms are activated by SE contributing to cell death and ...
    • Control of infection by pyroptosis and autophagy: role of TLR and NLR 

      Bortoluci, Karina R. [UNIFESP]; Medzhitov, Ruslan (Springer, 2010-05-01)
      Cells can die by distinct mechanisms with particular impacts on the immune response. in addition to apoptosis and necrosis, recent studies lead to characterization of a new pro-inflammatory form of cell death, pyroptosis. ...
    • Cytotoxicity of phenothiazine derivatives associated with mitochondrial dysfunction: A structure-activity investigation 

      Faria, Priscila A. de; Bettanin, Fernanda; Cunha, Rodrigo L. O. R.; Paredes-Gamero, Edgar J. [UNIFESP]; Homem-de-Mello, Paula; Nantes, Iseli L.; Rodrigues, Tiago (Elsevier B.V., 2015-04-01)
      Phenothiazine derivatives are neuroleptic drugs used in the treatment of schizophrenia and anxiety. Several side effects are described for these drugs, including hepatotoxicity, which may be related to their cytotoxic ...
    • Different patterns of neuronal activation and neurodegeneration in the thalamus and cortex of epilepsy-resistant Proechimys rats versus Wistar rats after pilocarpine-induced protracted seizures 

      Andrioli, Anna; Fabene, Paolo F.; Spreafico, Roberto; Cavalheiro, Esper Abrão [UNIFESP]; Bentivoglio, Marina (Wiley-Blackwell, 2009-04-01)
      To analyze cellular mechanisms of limbic-seizure suppression, the response to pilocarpine-induced seizures was investigated in cortex and thalamus, comparing epilepsy-resistant rats Proechimys guyannensis with Wistar ...