Browsing by Subject "succinate dehydrogenase"
Now showing items 1-4 of 4
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Ascorbic acid and alpha-tocopherol attenuate methylmalonic acid-induced convulsions
(Lippincott Williams & Wilkins, 1999-07-13)THE effects of chronic administration of alpha-tocopherol or melatonin, or acute ascorbic acid administration on the convulsant action of methylmalonic acid (MMA) were investigated in adult male rats. Animals were chronically ...
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Effects of short-term zidovudine exposure on mitochondrial DNA content and succinate dehydrogenase activity of rat skeletal muscle cells
(Elsevier B.V., 2008-05-15)Long-term use of zidovudine (AZT) may cause mitochondrial abnormalities in various tissues, including a toxic myopathy in AIDS patients associated with mitochondrial DNA (mtDNA) depletion. in the present study, we examine ...
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Progressive myopathy with a combined respiratory chain defect including Complex II
(Elsevier B.V., 2008-01-15)Biochemical defects in the respiratory chain are mostly associated with deficiencies in Complexes I, III and IV, caused by nuclear or mitochondrial DNA mutations. Combined defects including Complex II have been reported ...
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Succinate increases neuronal post-synaptic excitatory potentials in vitro and induces convulsive behavior through N-methyl-D-aspartate-mediated mechanisms
(Elsevier B.V., 2004-01-01)Succinate is a dicarboxylic acid that accumulates due to succinate dehydrogenase inhibition by malonate and methylmalonate exposure. These neurotoxins cause increased excitability and excitotoxic damage, which can be ...
