Browsing by Subject "spermatogenesis"
Now showing items 1-10 of 14
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Alterations of spermatogenesis in etoposide-treated rats: A stereological study
(Interciencia, 2002-05-01)The etoposide is an anticancer drug that interacts with topoisomerase II. Thirty-day-old rats received intraperitonially 2mg/kg of etoposide for 30 consecutive days. Their testes were analyzed in the adult phase under light ...
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Apoptosis and testicular alterations in albino rats treated with etoposide during the prepubertal phase
(Wiley-Blackwell, 2004-07-01)Etoposide is a podophyllotoxin semiderivative that is used in a variety of chemotherapy treatments, including therapy for children tumors. This drug promotes the formation of a ternary DNA-topoisomerase II-etoposide complex ...
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The BIR domain of IAP-like protein 2 is conformationally unstable: implications for caspase inhibition
(Portland Press, 2005-01-01)Several IAP (inhibitor of apoptosis) proteins regulate cell fate decisions, and the X-linked IAP (XIAP) does so in part by inhibiting caspases, proteases that execute the apoptotic pathway. A tissue-specific homologue of ...
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Carbamazepine damage to rat spermatogenesis in different sexual developmental phases
(Wiley-Blackwell, 2009-10-01)P>Carbamazepine (CBZ) is a first-line antiepileptic drug (AED), although it is also utilized for treatment of psychiatric disorders and neuropathic pain. the utilization of CBZ has been associated with damage to male ...
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Cimetidine (Tagamet) is a reproductive toxicant in male rats affecting peritubular cells
(Soc Study Reproduction, 2000-11-01)Cimetidine (Tagamet) is a potent histaminic H2-receptor antagonist, extensively prescribed for ulcers and now available without prescription. Cimetidine is a known testicular toxicant, but its mechanism of action remains ...
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Efeito da nicotina sobre o epitélio seminífero de ratos expostos durante a fase intrauterina e a lactação
(Universidade Federal de São Paulo (UNIFESP), 2015-05-27)SUMMARY Nicotine is a high licit drugs worldwide consumption through the cigarette. She is able to cross the placental membrane and is present in the smoking mothers milk. This drug induces apoptosis in various organs ...
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Histomorphometry of sexually immature albino rat testis after X ray-irradiation
(Interciencia, 1997-03-01)A A morphometric study was conducted of sexually immature albino rat testes which were exposed to a localized single. X-ray dose of 154.00 mC/Kg.The rats were killed at the ages of 25, 30, 35, 45, 60, 90 and 120 days. Their ...
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Impacto da varicocele unilateral esquerda, induzida na peripuberdade, sobre a morfologia e a função de células de sertoli de ratos adultos e sua repercussão sobre a espermatogênese
(Universidade Federal de São Paulo (UNIFESP), 2015-11-27)Idiopatic varicocele corresponds to the dilation in the veins of the pampiniform plexus and is closely associated to male infertility, probably due to the venous stasis, to the increase in the testicular temperature and ...
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Is rainfall seasonality important for reproductive strategies in viviparous Neotropical pit vipers? A case study with Bothrops leucurus from the Brazilian Atlantic Forest
(British Herpetol Soc, 2014-04-01)Two populations of the Neotropical lancehead Bothrops leucurus were studied in two locations in Brazil (Espirito Santo, ES, and Bahia, BA) with different rainfall seasonality patterns. The timing of reproduction was very ...
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Reproductive Function of the Male Obese Zucker Rats: Alteration in Sperm Production and Sperm DNA Damage
(Sage Publications Inc, 2014-02-01)Obesity has been considered a public health issue in many countries and is of increasing concern for authorities over the past 6 years. the Zucker rat is a good experimental model for obesity and diabetes studies due to ...
