Browsing by Subject "signal transduction"

Now showing items 1-10 of 13

    • Aberrant signaling pathways in medulloblastomas: a stem cell connection 

      Rodini, Carolina de Oliveira [UNIFESP]; Suzuki, Daniela Emi [UNIFESP]; Nakahata, Adriana Miti [UNIFESP]; Pereira, Márcia Cristina Leite [UNIFESP]; Janjoppi, Luciana [UNIFESP]; Toledo, Silvia Regina Caminada de [UNIFESP]; Okamoto, Oswaldo Keith [UNIFESP] (Academia Brasileira de Neurologia - ABNEURO, 2010-12-01)
      Medulloblastoma is a highly malignant primary tumor of the central nervous system. It represents the most frequent type of solid tumor and the leading cause of death related to cancer in early childhood. Current treatment ...

    • Activation of distinct signal transduction pathways in Trypanosoma cruzi isolates with differential capacity to invade host cells 

      Neira, I; Ferreira, A. T.; Yoshida, N. (Elsevier B.V., 2002-04-01)
      Mammalian cell invasion by Trypanosoma cruzi requires the activation of signal transduction pathways that result in a Ca2+ response both in the parasite and the host cell. By using drugs that interfere with the signalling ...

    • The kinin B-1 receptor regulates muscle-specific E3 ligases expression and is involved in skeletal muscle mass control 

      Parreiras-e-Silva, Lucas T.; Reis, Rosana I.; Santos, Geisa A.; Pires-Oliveira, Marcelo [UNIFESP]; Pesquero, Joao B. [UNIFESP]; Gomes, Marcelo D.; Godinho, Rosely O. [UNIFESP]; Costa-Neto, Claudio M. (Portland Press Ltd, 2014-08-01)
      Regulation of muscle mass depends on the balance between synthesis and degradation of proteins, which is under the-control of different signalling pathways regulated by hormonal, neural and nutritional stimuli. Such stimuli ...

    • Metabotropic glutamate receptors transduce signals for neurite outgrowth after binding of the prion protein to laminin gamma 1 chain 

      Beraldo, Flavio H.; Arantes, Camila P.; Santos, Tiago G.; Machado, Cleiton F.; Roffe, Martin [UNIFESP]; Hajj, Glaucia N.; Lee, Kil S.; Magalhaes, Ana C.; Caetano, Fabiana A.; Mancini, Gabriel. L.; Lopes, Marilene H.; Americo, Tatiana A.; Magdesian, Margaret H.; Ferguson, Stephen S. G.; Linden, Rafael; Prado, Marco A. M.; Martins, Vilma R. (Federation Amer Soc Exp Biol, 2011-01-01)
      The prion protein (PrP(C)) is highly expressed in the nervous system, and its abnormal conformer is associated with prion diseases. PrP(C) is anchored to cell membranes by glycosylphosphatidylinositol, and transmembrane ...

    • Molecular basis of mammalian cell invasion by Trypanosoma cruzi 

      Yoshida, Nobuko [UNIFESP] (Academia Brasileira de Ciências, 2006-03-01)
      Establishment of infection by Trypanosoma cruzi, the agent of Chagas' disease, depends on a series of events involving interactions of diverse parasite molecules with host components. Here we focus on the mechanisms of ...

    • Molecular basis of non-virulence of Trypanosoma cruzi clone CL-14 

      Atayde, V. D.; Neira, I; Cortez, M.; Ferreira, D.; Freymuller, E.; Yoshida, N. (Elsevier B.V., 2004-06-01)
      We investigated the properties of metacyclic trypomastigotes of non-virulent Trypanosoma cruzi. clone CL-14, as compared to the parental isolate CL. in contrast to the CL isolate, which produces high parasitemias in mice, ...

    • Participation of transmembrane proline 82 in angiotensin II AT(1) receptor signal transduction 

      Reis, Rosana I.; Santos, Edson L.; Pesquero, Joao B.; Oliveira, Laerte; Schanstra, Joost P.; Bascands, Jean-Loup; Pecher, Christiane; Paiva, Antonio C. M.; Costa-Neto, Claudio M. (Elsevier B.V., 2007-04-05)
      Most of the classical physiological effects of the octapeptide angiotensin II (AngII) are produced by activating the AT, receptor which belongs to the G-protein coupled receptor family (GPCR). Peptidic GPCRs may be ...

    • Proliferative signaling initiated in ACTH receptors 

      Lotfi, Claudimara Ferini Pacicco [UNIFESP]; Lepique, Ana Paula; Forti, Fabio Luis; Schwindt, Telma Tiemi [UNIFESP]; Eichler, C. B.; Santos, M. O.; Rebustini, I. T.; Hajj, GNM; Juliano, Luiz [UNIFESP]; Armelin, Hugo Aguirre (Assoc Bras Divulg Cientifica, 2000-10-01)
      This article reviews recent results of studies aiming to elucidate modes of integrating signals initiated in ACTH receptors and FGF2 receptors, within the network system of signal transduction found in Y1 adrenocortical ...

    • Protein tyrosine kinases in Schistosoma mansoni 

      Bahia, Diana [UNIFESP]; Andrade, Luiza Freire; Ludolf, Fernanda; Mortara, Renato Arruda [UNIFESP]; Oliveira, Guilherme [UNIFESP] (Instituto Oswaldo Cruz, Ministério da Saúde, 2006-10-01)
      The identification and description of signal transduction molecules and mechanisms are essential to elucidate Schistosoma mansoni host-parasite interactions and parasite biology. This mini review focuses on recent advancements ...

    • Seek and Destroy: The Use of Natural Compounds for Targeting the Molecular Roots of Cancer 

      Souza, Ana C. S.; Fatima, Angelo de; Silveira, Rafael Bertoni da [UNIFESP]; Justo, Giselle Zenker [UNIFESP] (Bentham Science Publ Ltd, 2012-07-01)
      One of the major issues facing anticancer research relies on the intrinsic inability of tumor cells to undergo apoptosis. Additionally, the development of cancer resistance to standard therapy and the great heterogeneity ...