Now showing items 1-10 of 14

    • ADIPOQ and adiponectin: the common ground of hyperglycemia and coronary artery disease? 

      Oliveira, Carolina Soares Viana de [UNIFESP]; Giuffrida, Fernando M. A. [UNIFESP]; Crispim, Felipe [UNIFESP]; Saddi-rosa, Pedro [UNIFESP]; Reis, André Fernandes [UNIFESP] (Sociedade Brasileira de Endocrinologia e Metabologia, 2011-10-01)
      Plasma adiponectin and the coding gene for adiponectin, ADIPOQ, are thought to explain part of the interaction between obesity, insulin resistance, type 2 diabetes (T2DM) and coronary artery disease (CAD). Here, we illustrate ...

    • Association Between Interleukin 6 Gene Haplotype and Alzheimer's Disease: A Brazilian Case-Control Study 

      Rasmussen, Lucas [UNIFESP]; Delabio, Roger; Horiguchi, Lie; Mizumoto, Igor; Terazaki, Carlos-Renato; Mazzotti, Diego [UNIFESP]; Bertolucci, Paulo-Henrique [UNIFESP]; Pinhel, Marcela-Augusta; Souza, Doroteia; Krieger, Henrique; Kawamata, Carlos; Minett, Thais; Smith, Marilia Cardoso [UNIFESP]; Payao, Spencer-Luiz (Ios Press, 2013-01-01)
      Alzheimer's disease (AD) is a progressive neurodegenerative disease that takes the form of a local overexpression of cytokines and other inflammatory molecules. We investigated three single-nucleotide polymorphisms (SNP) ...

    • Casein kinase I epsilon (CKI epsilon) N408 allele is very rare in the Brazilian population and is not involved in susceptibility to circadian rhythm sleep disorders 

      Castro, Rosa M. R. P. S. [UNIFESP]; Barbosa, Ana A. [UNIFESP]; Pedrazzoli, Mario [UNIFESP]; Tufik, Sergio [UNIFESP] (Elsevier B.V., 2008-11-03)
      Circadian rhythms are regulated by clock proteins through post-translational modifications. Indeed, Casein kinase I epsilon (CKI epsilon) promotes reversible phosphorylation of PER proteins, and a deficiency in this ...

    • Cytokine gene variants and venous thrombotic risk in the BRATROS (BRAZILIAN THROMBOSIS STUDY) 

      Pieroni, Fabiano; Lourenco, Dayse M.; Morelli, Vania M.; Maffei, Francisco H.; Zago, Marco A.; Franco, Rendrik F. (Elsevier B.V., 2007-01-01)
      Introduction: Venous thrombosis (VT) and inflammation are two closely related entities. in the present investigation we assessed whether there is a relation between genetic modifiers of the inflammatory response and the ...

    • Efeito de polimorfismos genéticos no metabolismo do ácido fólico e sua relação com as concentrações de folato, vitamina b12 e homocisteína total em indivíduos submetidos à fortificação e/ou terapêutica com ácido fólico 

      Lucena, Mraylla Rodrigues [UNIFESP] (Universidade Federal de São Paulo (UNIFESP), 2015-11-27)
      Folic acid (FA) is an essential micronutrient for several functions of the organism, such as nucleic acids synthesis and methylation reactions. Several important enzymes participate of folate metabolism such as glutamate ...

    • Frequency of polymorphisms of genes coding for HIV-1 co-receptors CCR5 and CCR2 in a Brazilian population 

      Munerato, Patricia [UNIFESP]; Azevedo, Maria Lúcia [UNIFESP]; Sucupira, Maria Cecília Araripe [UNIFESP]; Pardini, Regina [UNIFESP]; Pinto, Gedson Humberto Novaes [UNIFESP]; Catroxo, Márcia [UNIFESP]; Souza, Inara Espinelli [UNIFESP]; Diaz, Ricardo Sobhie [UNIFESP] (Brazilian Society of Infectious Diseases, 2003-08-01)
      Entry of human immunodeficiency type 1 virus (HIV-1) into target cells requires both CD4and one of the chemokine receptors. Viruses predominantly use one, or occasionally both, of the major co-receptors CCR5 and CXCR4, ...

    • Genotype-guided warfarin therapy: current status 

      Tavares, Leticia C.; Marcatto, Leiliane R.; Santos, Paulo C. J. L. [UNIFESP] (Future Medicine Ltd, 2018)
      Warfarin pharmacogenomics has been an extensively studied field in the last decades as it is focused on personalized therapy to overcome the wide interpatient warfarin response variability and decrease the risk of side ...

    • The Gly482Ser polymorphism in the peroxisome proliferator-activated receptor-gamma coactivator-1 gene is associated with hypertension in type 2 diabetic men 

      Cheurfa, Nadir; Reis, André Fernandes [UNIFESP]; Dubois-Laforgue, Daniele; Bellanne-Chantelot, Christine; Timsit, José; Velho, Gilberto [UNIFESP] (Springer, 2004-11-01)
      Aims/hypothesis. Peroxisome proliferator-activated receptor-gamma coactivator-1 (PPARGC1) acts as a cofactor for several nuclear hormone receptors in many tissues and organs implicated in blood pressure regulation. Here, ...

    • Interleukin-6 polymorphisms and the risk of cervical cancer 

      Souza, NCN de; Brenna, SMF; Campos, F.; Syrjanen, K. J.; Baracat, Edmund Chada [UNIFESP]; Silva, Ismael Dale Cotrim Guerreiro da [UNIFESP] (Blackwell Publishing, 2006-05-01)
      Recent data implicate that cytokine gene polymorphisms are important in pathogenesis of various neoplastic and nonneoplastic human diseases, and it was recently suggested that polymorphisms in interleukin (IL)-6 might ...

    • Mutations in the HFE gene (C282Y, H63D, S65C) in a Brazilian population 

      Bueno, Simone [UNIFESP]; Duch, Cibele R. [UNIFESP]; Figueiredo, Maria Stella [UNIFESP] (Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular, 2006-12-01)
      Hereditary hemochromatosis (HH) is the most common genetic disorder occurring in individuals of northern European descent. The clinical characteristic of this disease is the gradual accumulation of iron in internal organs, ...