Now showing items 1-5 of 5

    • Activation profiles of human kallikrein-related peptidases by proteases of the thrombostasis axis 

      Yoon, Hyesook; Blaber, Sachiko I.; Evans, D. Michael; Trim, Julie; Juliano, Maria Aparecida [UNIFESP]; Scarisbrick, Isobel A.; Blaber, Michael (Cold Spring Harbor Lab Press, Publications Dept, 2008-11-01)
      The human kallikrein-related peptidases (KLKs) comprise 15 members (KLK1-15) and are the single largest family of serine proteases. the KLKs are utilized, or proposed, as clinically important biomarkers and therapeutic ...

    • Characterization of a Kunitz trypsin inhibitor with one disulfide bridge purified from Swartzia pickellii 

      Cavalcanti, MDM; Oliva, MLV; Fritz, H.; Jochum, M.; Mentele, R.; Sampaio, M.; Coelho, LCBB; Batista, IFC; Sampaio, CAM (Elsevier B.V., 2002-03-01)
      Swartzia pickellii is a Leguminosae that belongs to the Caesalpinioideae sub-family the Swartzia pickellii Trypsin Inhibitor (SWTI), a serine proteinase inhibitor was isolated from its seeds. SWTI is a single polypeptide ...

    • Effect of invertebrate serine proteinase inhibitors on carrageenan-induced pleural exudation and bradykinin release 

      Malavazi-Piza, K. C.; Araujo, M. S.; Godinho, R. O.; Tanaka, A. S. (Elsevier B.V., 2004-10-01)
      The carrageenan model of pleurisy is described as temporal plasma exudation (1-5 h) with extensive neutrophil infiltration and release of proteinases into the pleural cavity. the aim of this work was to study the effects ...

    • Fibrinolytic activity is associated with presence of cystic medial degeneration in aneurysms of the ascending aorta 

      Borges, Luciano F. [UNIFESP]; Gomez, Delphine; Quintana, Mercedes; Touat, Ziad; Jondeau, Guillaume; Leclercq, Anne; Meilhac, Olivier; Jandrot-Perrus, Martine; Gutierrez, Paulo S.; Freymuller, Edna [UNIFESP]; Vranckx, Roger; Michel, Jean-Baptiste (Wiley-Blackwell, 2010-12-01)
      Fibrinolytic activity is associated with presence of cystic medial degeneration in aneurysms of the ascending aortaAims:Thoracic ascending aortic aneurysms (TAA) are characterized by elastic fibre breakdown and cystic ...

    • Functional intersection of the kallikrein-related peptidases (KLKs) and thrombostasis axis 

      Blaber, Michael; Yoon, Hyesook; Juliano, Maria A. [UNIFESP]; Scarisbrick, Isobel A.; Blaber, Sachiko I. (Walter de Gruyter & Co, 2010-04-01)
      A large body of emerging evidence indicates a functional interaction between the kallikrein-related peptidases (KLKs) and proteases of the thrombostasis axis. These interactions appear relevant for both normal health as ...